The Role of BMP7 in the Proliferation of Hu Sheep Dermal Papilla Cells Is Influenced by DNA Methylation

    June 2024 in “ Animals ”
    Xiaoyang Lv, Mingliang He, Shanhe Wang, Wenxin Zheng, Hanlin Zhou, Joram M. Mwacharo, Wei Sun
    Studysummary This study found that DNA methylation may regulate the differential expression of the BMP7 gene in Hu sheep lamb skin of different patterns, and it influences the proliferation and cell cycle of dermal papilla cells, with demethylation treatment increasing BMP7 expression and cell proliferation.
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    This study examines how DNA methylation affects the BMP7 gene expression and the proliferation of dermal papilla cells (DPCs) in Hu sheep, which is crucial for hair follicle development. The research found that demethylation using 5-Aza-Deoxycytidine increases BMP7 expression, enhancing DPC proliferation and cell cycle progression. In contrast, overexpression of DNMT1, which promotes methylation, reduces BMP7 expression and inhibits DPC proliferation. These findings suggest that DNA methylation negatively regulates BMP7 expression and DPC proliferation, providing insights into hair follicle growth and potential hair loss treatments. The experiments were conducted with a sample size of 3 for each condition.
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