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Differentiation of Human Dermal Mesenchymal Stem Cells into Cardiomyocytes by Treatment with 5-Azacytidine: Concept for Regenerative Therapy in Myocardial Infarction

research Differentiation of Human Dermal Mesenchymal Stem Cells into Cardiomyocytes by Treatment with 5-Azacytidine: Concept for Regenerative Therapy in Myocardial Infarction

9 citations , March 2013 in “ISRN Stem Cells (Online)”

This study demonstrated that human dermal mesenchymal stem cells can be differentiated into cardiomyocytes using 5-azacytidine, suggesting potential future applications for treating myocardial infarction.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.

research Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

1 citations , October 2020 in “Current Drug Discovery Technologies”

This study investigated various synthesized 5-reductase inhibitors and found that compound 6 had the highest anti-androgenic activity and receptor affinity compared to finasteride, showing potential due to its improved efficacy and bioavailability for further research in treating lower urinary tract symptoms.

research Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin

34 citations , February 1993 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that 4-MA is a potent inhibitor of testosterone 5α-reductase in human tissues, promising potential for treating androgen-dependent skin conditions like male pattern baldness.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

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Community Join

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community Norwood reaper hit me young, but I’ve hit back harder (4 months of OM 5 mg, Fin 1 mg)

in Progress Pictures 762 upvotes 2 years ago

A user shared their progress in combating hair loss using 5 mg oral minoxidil and 1 mg finasteride over four months, experiencing significant improvement. They also experimented with higher doses of minoxidil but faced side effects, so they settled on 7.5 mg without issues.

community Dermaneedling+minox+tretinoin+azaleic acid and hair loss

1 upvotes 8 months ago

The user stopped oral treatments due to side effects and switched to a regimen of topical minoxidil, tretinoin, azelaic acid, and dermaneedling, with recent addition of topical finasteride. They are questioning the long-term effectiveness of non-hormonal methods and considering hair transplantation.

community Minoxidil retinoid and azaleic acid

3 upvotes 3 years ago

community Alcohol Free Minoxidil? Azaleic Acid added?

4 upvotes 9 years ago

The user is experiencing a burning sensation from using minoxidil and is considering trying an alcohol-free version with added azelaic acid. They are also using finasteride and seeking reliable, low-cost alternatives for minoxidil.

community For those who apply minoxidil after microneedling

2 upvotes 1 month ago

Applying a minoxidil, tretinoin, and azelaic acid solution immediately after microneedling may cause irritation, and it's generally advised to wait before application. Some users suggest that tretinoin increases minoxidil absorption, but it can also cause side effects like lightheadedness.

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Learn

6 / 801 results

learn Hair Transplant

Is a hair transplant painful? A hair transplant is generally comfortable due to local anesthesia, with mild post-procedure soreness possible.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Biopeptide-5

learn O-Cymen-5-Ol

learn Minoxidil

Minoxidil 2%, 5% and 10% which is better to use? In a randomized trial in men, 5% topical minoxidil produced more hair growth than 2%. There is no approved 10% product and no head-to-head trial showing it beats 5%; higher strengths mainly add irritation and systemic absorption. Approved strengths differ by sex, so check the label for your product.

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Experts

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Clinics

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