Low Molecular Weight Collagen Peptide Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway

September 2023 in “ Journal of microbiology and biotechnology ”

Yu Jin Kim, Jung Ok Lee, Jung Min Lee, Mun-Hoe Lee, Hyeong-Min Kim, Haerim Chung, Do-Un Kim, Jin‐Hee Lee, Beom Joon Kim

low molecular weight collagen peptide LMWCP hair growth Wnt/GSK-3β/β-catenin signaling pathway cell proliferation mitochondrial potential human dermal papilla cells hair follicles oral administration hair growth-related proteins hair growth-related genes collagen peptide Wnt signaling pathway dermal papilla cells

Studysummary This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.

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The study investigated the effects of low molecular weight collagen peptide (LMWCP) on hair growth and found that LMWCP promotes hair growth by enhancing cell proliferation, mitochondrial potential, and secretion of hair growth-related factors in human dermal papilla cells. It also increased the formation of new hair follicles in a dose-dependent manner and upregulated key proteins and genes in the Wnt/GSK-3β/β-catenin signaling pathway. Additionally, oral administration of LMWCP in mice significantly stimulated hair growth and increased the expression of hair growth-related proteins and genes. These results suggest that LMWCP could be a potential treatment for promoting hair growth by activating the Wnt/β-catenin signaling pathway.

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