Image

    Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents

    July 2025 in “ Pharmaceuticals ”
    Salma A. Fereig, John Youshia, Ghada M. El-Zaafarany … Mona M.A. Abdel-Mottaleb
    Studysummary In this study, chitosan nanoparticles loaded with phenobarbital were the most effective in promoting hair regrowth and quality in a mouse model of chemotherapy-induced alopecia, suggesting potential for preventing hair loss in cancer patients.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 35

    1. A Lipid–Polymer Hybrid Nanoparticle-Loaded Dissolving Microneedle Patch for Promoting Hair Regrowth by Transdermal miR-218 Delivery Biomaterials Science · 2022
    2. Efficacy of Topical Clobetasol Propionate 0.05% Ointment and Topical Tacrolimus 0.1% Ointment in Treatment of Alopecia Areata: Randomized Controlled Trial Pakistan Journal of Medical and Health Sciences · 2022
    3. Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model Acta Biomaterialia · 2022
    4. Chemotherapy, Alopecia, and Scalp Cooling Systems Actas Dermo-Sifiliográficas · 2022
    5. Coenzyme Q10 Phospholipidic Vesicular Formulations for Treatment of Androgenic Alopecia: Ex Vivo Permeation and Clinical Appraisal Expert Opinion on Drug Delivery · 2021
    6. Treatment of Pediatric Alopecia Areata: A Systematic Review Journal of the American Academy of Dermatology · 2021
    7. A Botanical Compound for the Treatment of Alopecia Areata and Chemotherapy-Induced Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2020
    8. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020
    9. Human Placenta Induces Hair Regrowth in Chemotherapy-Induced Alopecia via Inhibition of Apoptotic Factors and Proliferation of Hair Follicles BMC Complementary Medicine and Therapies · 2020
    10. Prevention and Treatment of Chemotherapy-Induced Alopecia Dermatology practical & conceptual · 2020
    11. PPAR-γ Signaling as a Key Mediator of Human Hair Follicle Physiology and Pathology Experimental Dermatology · 2019
    12. Hair Growth-Promoting Activities of Chitosan and Surface-Deacetylated Chitin Nanofibers International Journal of Biological Macromolecules · 2018
    13. Pathogenesis and Treatment Options for Chemotherapy-Induced Alopecia: A Systematic Review International Journal of Dermatology · 2018
    14. The Androgenic Alopecia Protective Effects of Forsythiaside-A and the Molecular Regulation in a Mouse Model Phytotherapy Research · 2015
    15. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    16. Differential Expression and Functionality of ATP-Binding Cassette Transporters in the Human Hair Follicle British Journal of Dermatology · 2014
    17. Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle Trends in pharmacological sciences · 2013
    18. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract Phytotherapy Research · 2012
    19. A Function for Rac1 in the Terminal Differentiation and Pigmentation of Hair Journal of cell science · 2012
    20. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    21. Treatment of Chemotherapy-Induced Alopecia Dermatologic Therapy · 2011
    22. P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss FEBS Letters · 2010
    23. Prevention of Chemotherapy-Induced Alopecia in Rodent Models Cell stress & chaperones · 2008
    24. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    25. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006
    26. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    27. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    28. Restoration of Hair Growth in Mice with an Alopecia Areata-Like Disease Using Topical Anthralin Experimental Dermatology · 2004
    29. Tacrolimus in Dermatology Journal of Cutaneous Medicine and Surgery · 2001
    30. P53 Involvement in the Control of Murine Hair Follicle Regression American Journal of Pathology · 2001
    31. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000
    32. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    33. The Protective Role of the Immunomodulator AS101 Against Chemotherapy-Induced Alopecia: Studies on Human and Animal Models International Journal of Cancer · 1996
    34. Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone PubMed · 1994
    35. Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia Cancer investigation · 1992