Loss of Keratin 10 Is Accompanied by Increased Sebocyte Proliferation and Differentiation

    January 2004 in “ European journal of cell biology ”
    Julia Reichelt, Bernadette Breiden, Konrad Sandhoff, Thomas M. Magin
    Studysummary This study found that in mice, deleting the keratin 10 gene enhances sebocyte differentiation and increases secretion of sebum and certain lipids without affecting proliferation-associated keratins.
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    Research cited in this study 11

    1. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    2. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    3. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002
    4. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    5. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    6. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    7. Abnormal Differentiation of Epidermis in Transgenic Mice Constitutively Expressing Cyclooxygenase-2 in Skin Proceedings of the National Academy of Sciences · 2001
    8. Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix Journal of Investigative Dermatology · 2001
    9. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    10. Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998
    11. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998