Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

    Talveen S. Purba, Lars Brunken, Michael Peake … Ralf Paus
    Studysummary This study observed that CIP/KIP proteins play a significant role in regulating cell cycle arrest and differentiation in human hair follicles, supporting hair growth and formation in the anagen phase.
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    Research cited in this study 33

    1. The Hair Follicle Enigma Experimental Dermatology · 2017
    2. A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle Experimental Dermatology · 2016
    3. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    4. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015
    5. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    6. Keratins: The Hair Shaft's Backbone Revealed Experimental Dermatology · 2015
    7. Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness? Experimental Dermatology · 2014
    8. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    9. Beta-1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis, and Migration of Their Progeny PLoS ONE · 2013
    10. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    11. A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013
    12. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    13. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    14. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    15. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    16. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    17. Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions PLOS ONE · 2011
    18. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    19. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    20. Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control ˜The œFASEB journal · 2009
    21. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    22. Endocrine Controls of Keratin Expression BioEssays · 2009
    23. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    24. Molecular Elements of the Regulatory Control of Keratin Filament Modulator AHF/Trichohyalin in the Hair Follicle Experimental Dermatology · 2008
    25. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    26. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    27. Survivin in the Human Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    28. Keratins of the Human Hair Follicle International review of cytology · 2005
    29. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    30. Cyclin-Dependent Kinase Inhibitors, P21waf1/Cip1 And P27kip1, Are Expressed Site- And Hair Cycle-Dependently In Rat Hair Follicles Journal of Dermatological Science · 2001
    31. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    32. Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance Dermatologic clinics · 1996
    33. Prolonged Maintenance of Human Hair Follicles In Vitro in a Serum-Free Medium British Journal of Dermatology · 1993