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    Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury

    May 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Natalia A. Veniaminova, Yunlong Jia, Adrien M Hartigan … Sunny Y. Wong

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that sebaceous glands in the skin are primarily renewed by their own stem cells during normal conditions, but after injury, they regenerate through stem cells from hair follicles, highlighting stem cell plasticity and regeneration capabilities.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 29

    1. Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations Frontiers in immunology · 2022
    2. Revisiting the Significance of Keratin Expression in Complex Epithelia Journal of cell science · 2022
    3. Preparing the Hair Follicle Canal for Hair Shaft Emergence Experimental dermatology · 2020
    4. Blimp1+ Cells Generate Functional Mouse Sebaceous Gland Organoids In Vitro Nature communications · 2019
    5. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    6. JunB Defines Functional And Structural Integrity Of The Epidermal-Pilosebaceous Unit In The Skin Nature Communications · 2018
    7. Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth EMBO journal · 2018
    8. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Journal of Investigative Dermatology · 2016
    9. Facial Pores Dermatologic surgery · 2016
    10. Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice Development · 2016
    11. Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration Cell Cycle · 2015
    12. The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology Experimental Dermatology · 2015
    13. Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease Cell and Tissue Research · 2014
    14. BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions Stem cell reports · 2014
    15. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    16. A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ Experimental Dermatology · 2013
    17. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    18. The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia Current opinion in cell biology · 2012
    19. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    20. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    21. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    22. Expression of the Orphan Protein Plet-1 During Trichilemmal Differentiation of Anagen Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    23. Hedgehog Signaling, Keratin 6 Induction, And Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008
    24. The Role of Fibroblast Growth Factor Receptor 2b in Skin Homeostasis and Cancer Development The EMBO Journal · 2007
    25. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    26. A Null Mutation in the Cystatin M/E Gene of Ichq Mice Causes Juvenile Lethality and Defects in Epidermal Cornification Human molecular genetics online/Human molecular genetics · 2002
    27. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    28. Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias Archives of dermatology · 1999
    29. Keratin 17 Gene Expression During the Murine Hair Cycle Journal of Investigative Dermatology · 1997

    Related research 1

    1. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010