Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

    December 2011 in “ American Journal Of Pathology ”
    Yue Zhou, Xuan Jiang, Pengyu Gu … Xiang Gao
    Studysummary This study found that immune-mediated destruction of bulge stem cells is a key factor in the alopecia observed in AE mice, suggesting it as a model for studying primary cicatricial alopecias, particularly lichen planopilaris.
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    Research cited in this study 21

    1. Gsdma3 Is Required for Hair Follicle Differentiation in Mice Biochemical and biophysical research communications · 2010
    2. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    3. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    4. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009
    5. Lichen Planopilaris: Update on Diagnosis and Treatment Seminars in Cutaneous Medicine and Surgery · 2009
    6. Hair Follicle Stem Cells in the Pathogenesis of the Scarring Process in Cutaneous Lupus Erythematosus Autoimmunity Reviews · 2009
    7. Etiology of Cicatricial Alopecias: A Basic Science Point of View Dermatologic therapy · 2008
    8. Cicatricial Alopecia: Classification and Histopathology Dermatologic therapy · 2008
    9. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    10. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    11. Stem Cells and Their Niches Science · 2006
    12. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    13. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    14. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    15. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    16. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    17. Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles Journal of Investigative Dermatology · 2002
    18. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    19. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    20. Intercellular Adhesion Molecule-1 and Hair Follicle Regression Journal of histochemistry and cytochemistry/˜The œjournal of histochemistry and cytochemistry · 2000
    21. A New Mutation Rim3 Resembling Re Den Is Mapped Close to Retinoic Acid Receptor Alpha (Rara) Gene on Mouse Chromosome 11 Mammalian Genome · 1998