76 citations
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January 2019 in “Nanoscale” Created material boosts hair growth and kills bacteria for wound healing.
2 citations
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May 2024 in “Nanomaterials” This study reports the synthesis of a hectorite/phenanthroline nanomaterial which acts as a potential fluorescent sensor for detecting Zn ions in water, offering a solution to the low solubility issue of traditional metal ion-detecting molecules.
50 citations
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December 2020 in “Bioactive Materials” This study suggests that a sandwich-structured wound dressing with bioceramic and polylactic acid layers may improve burn wound healing by absorbing exudates and promoting hair follicle regeneration.
7 citations
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January 2025 in “ACS Applied Materials & Interfaces” This study developed a zinc-infused egg white and GelMA hydrogel that enhanced cellular processes crucial for wound healing, including fibroblast proliferation and collagen expression, and demonstrated promising biocompatibility and bioactivity in vivo, suggesting potential effectiveness in repairing damaged tissues.
January 2008 in “Информационно-управляющие системы” This review outlines the physiological roles of zinc transporters and their involvement in human diseases, emphasizing their molecular, biochemical, and genetic mechanisms without presenting new research findings.
This study reports that in a rat model of myocardial infarction, Zn-Cu ion sequential therapy improved cardiac function and cardiomyocyte metabolic activity by precisely regulating ion concentrations and maintaining elevated levels of the Per2 protein, important for cellular repair.
3 citations
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July 2023 in “International Journal of Biological Macromolecules” In this study, the researchers developed a hydrogel mimicking the fetal environment that significantly accelerated wound healing and hair follicle regeneration in vivo, with over 94% wound closure in 14 days, surpassing hydrogels lacking certain additives.
8 citations
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January 2024 in “Regenerative Biomaterials” This study found that a novel bioceramic/alginate hydrogel with photothermal properties and multiple ion release effectively reduces infection and inflammation, and enhances osseointegration in early-stage peri-implant lesions, potentially improving dental implant survival rates.
4 citations
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August 2011 in “Journal of Food Biochemistry” This study reports that α-casein in bovine milk can form stable complexes with zinc, potentially useful for fortifying milk-based products to enhance zinc availability.
9 citations
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December 2024 in “Nano Research” In a study on diabetic mice, researchers developed a protein-based hydrogel that leverages zinc ions and the natural compound phellopterin to promote cutaneous nerve regeneration, angiogenesis, and tissue remodeling in diabetic wounds, highlighting its potential for advanced wound therapy.
March 2023 in “International Journal of bioprinting” This study found that a bioprinted hydrogel scaffold with zinc and silicon ions significantly activated hair follicle stem cells and enhanced blood vessel formation, promoting hair growth in mouse wound models.
45 citations
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March 2020 in “ACS Applied Materials & Interfaces” In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.
19 citations
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November 2022 in “Antioxidants” In this study, ginger peel polysaccharides modified with zinc reduced inflammation in zebrafish by altering cytokine expression, suggesting potential for treating chronic inflammation-related diseases.
15 citations
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June 2020 in “Applied Materials Today” This study found that SA-MS hydrogel released Mo4+ ions which promoted healing of disease-impaired wounds by enhancing cell proliferation and angiogenesis, and through its photothermal effects addressed skin cancer-impaired wounds in mice.
15 citations
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July 2012 in “Biological trace element research” This study found that an increased calcium/magnesium ratio in hair and lower chromium concentration were associated with higher insulin resistance in Korean adult males.
9 citations
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January 2013 This study found that serum levels of zinc, copper, and selenium were significantly lower in patients with alopecia areata compared to healthy controls, regardless of the number of hair loss patches.
8 citations
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May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
24 citations
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November 2023 in “Regenerative Biomaterials” In this review, the authors summarized the potential therapeutic effects of metal ions in treating cardiovascular diseases, highlighting their roles in protecting cells, inducing angiogenesis, and adjusting ion channel functions, as well as discussing delivery strategies involving biomaterials.
4 citations
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May 2024 in “Biomolecules” This study examined connections between bioelements like Zn, Cu, and Mn in serum and bone tissue and hormone concentrations in men with and without erectile dysfunction, highlighting potential relationships that may help explain ED's etiology.
August 2023 in “International Journal of Molecular Sciences” In this study, researchers developed a new sodium alginate/chitosan/Zn2+ hydrogel that showed improved physical properties, antibacterial activity, and biocompatibility, and demonstrated enhanced wound healing and skin regeneration in an in vitro model.
47 citations
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August 2024 in “Science Advances” This study introduces a new biomimetic double wound mask designed to promote scarless healing by coordinating multiple biological pathways and providing enhanced protection and nourishment to wounds.
12 citations
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September 2023 in “Polymers” This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.
1 citations
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August 2023 in “Composites Part B: Engineering” In this study, researchers developed a composite electrospun wound dressing containing strontium zinc silicon bioceramics, which significantly activated hair follicle stem cells and promoted hair follicle and capillary regeneration in deep burn wounds, suggesting a promising approach for burn wound healing.
April 2026 in “Biomolecules” This study reported that discarded squid ink was used to develop a high-performance, environmentally friendly hair dye that offers a stable deep black color, UV protection, and preserves hair structure, while showing excellent biosafety in lab tests.
May 2026 in “Scientific Reports” This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.
January 2025 in “Biomaterials Research” This study developed a novel zinc-releasing hydrogel, Zn-Gel, which promoted wound healing by controlling zinc ion release and demonstrated excellent compatibility and efficacy in enhancing cell proliferation, blood vessel formation, and tissue regeneration in vitro and in vivo settings.
1 citations
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July 2025 in “Advanced Materials” This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.
January 2022 in “Social Science Research Network” This study demonstrates that a newly developed nanocomposite microneedle patch, releasing copper and zinc ions along with quercetin, effectively promotes hair follicle regeneration in androgenic alopecia by targeting various pathophysiological aspects of hair loss.
In this study, a pH-responsive microneedle patch was developed, showing potential in rat models for treating spinal cord injuries by reducing inflammation, promoting nerve regeneration, and supporting neurogenesis, which contributed to improved motor and neurological recovery.
40 citations
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September 2024 in “Heliyon” This review discusses the role of bioceramics, highlighting their bactericidal activity, lack of side effects, and ability to release metallic ions for hard and soft tissue repair. The authors suggest that integrating bioceramics with other biomaterials could offer a cost-effective, efficient alternative for wound healing.