Interaction of Zn(II) with Bovine Milk α-Casein: Structure-Function Study

    August 2011 in “ Journal of Food Biochemistry ”
    Srinivas Sistla, V. Prakash
    TLDR Zinc binds to milk protein α-casein, forming stable complexes that could help fortify milk with zinc to prevent deficiencies.
    The study investigated the interaction between Zn(II) and α-casein, the primary casein in bovine milk, revealing 17 binding sites for Zn(II) with specific association constants. The presence of Zn(II) induced secondary structure formation in α-casein, as shown by circular dichroic measurements, and fluorescence quenching studies indicated a blue shift in emission maxima and a decrease in the Stern–Volmer constant. The binding kinetics followed a pseudo-first-order rate. These interactions resulted in stable complexes, suggesting potential for fortifying milk-based products with zinc, which could address zinc deficiency-related health issues such as hair loss, neonatal growth problems, and immune deficiencies.
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