Cuprorivaite/Hardystonite/Alginate Composite Hydrogel with Thermionic Effect for the Treatment of Peri-Implant Lesion

    January 2024 in “ Regenerative Biomaterials ”
    Yiru Xia, Zhaowenbin Zhang, Kecong Zhou, Zhikai Lin, Rong Shu, Yuze Xu, Zhen Zeng, Jiang Chang, Yufeng Xie
    TLDR The hydrogel effectively treats dental implant issues by killing bacteria, reducing inflammation, and improving implant success.
    The study explores a novel cuprorivaite/hardystonite/alginate composite hydrogel for treating peri-implant lesions, emphasizing its antibacterial and biological properties. The hydrogel, particularly effective when combined with near-infrared (NIR) laser irradiation, enhances osseointegration and reduces inflammation by releasing bioactive ions (Cu2+, Zn2+, and SiO32−) and utilizing photothermal effects. In a rat model with 36 subjects, the Cu–Zn hydrogel with NIR treatment showed the highest implant survival rate of 83.33%, significantly reducing bacterial content and promoting bone integration. The study concludes that this hydrogel, with its thermionic effects, is a promising treatment for improving implant integration amidst periodontal inflammation.
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