April 2026 in “Journal of Investigative Dermatology” This research observed that diabetes impairs wound healing in mice by disrupting key mechanotransduction pathways in fibroblasts, which are crucial for the healing process. The study also suggests transcriptomic changes could inform future diabetic wound repair therapies.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
April 2024 in “Materials today bio” In this study, the researchers developed a novel wound dressing incorporating copper-doped calcium silicate and curcumin, which significantly promoted nerve and blood vessel regeneration in deep burn wounds, emphasizing the crucial role of bioactive chelation in neuralized skin repair.
38 citations
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September 2011 in “PLOS ONE” This study found that activin B promotes epithelial wound healing in mice through the RhoA-Rock-JNK-cJun signaling pathway, suggesting a potential therapeutic role for activin B in wound repair.
19 citations
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February 2008 in “Facial Plastic Surgery” This article reviews various reconstructive surgery techniques for scalp wounds and emphasizes factors affecting aesthetic outcomes, but it presents no new clinical findings.
13 citations
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March 2020 in “Acta veterinaria Scandinavica” This study found that wounds in dogs treated with allogeneic adipose-derived mesenchymal stem cells showed faster and improved healing compared to wounds receiving conventional treatment.
12 citations
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November 2024 in “Burns & Trauma” This review highlights the critical role of neuroregulation in skin wound healing, emphasizing how neurotransmitters and neuropeptides regulate inflammation, angiogenesis, and cell proliferation, and discusses potential therapeutic strategies, such as neuromodulation, to enhance these processes.
8 citations
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July 2023 in “Inflammation and Regeneration” This study found that ALKBH5 plays a critical role in wound re-epithelialization by enhancing the stability of PELI2 mRNA, and its absence delays wound healing. Supplementation with PELI2 can partially rescue this delay, pointing to potential new therapies for stubborn wounds.
January 2012 in “Elsevier eBooks” This chapter reviews therapies for skin and corneal regeneration and hair loss, discussing various treatments but presenting no new research findings.
September 2006 in “Dermatologic Surgery” This study reported that squamous cell carcinomas of the scalp can be extraordinarily aggressive, potentially metastasizing and causing death, highlighting the need for early diagnosis and careful treatment approaches.
January 2023 in “Burns & Trauma” This study introduced a volar skin excisional wound model that closely mirrors human wound healing and supports evaluation of skin regeneration with multiple appendages and innervation.
132 citations
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April 2021 in “Stem Cell Research & Therapy” This study found that exosome-incorporated human amniotic membrane scaffolds notably enhanced diabetic skin wound healing in mice, suggesting potential applications for ADSC-derived exosomes in clinical settings.
47 citations
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October 2021 in “Journal of Nanobiotechnology” This study found that hollow polydopamine nanoparticles enhanced the regenerative potency of the peptide RL-QN15, suggesting potential for improved therapeutic approaches in skin wound healing.
4 citations
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February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
2 citations
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December 2022 in “Bio-Design and Manufacturing” This study demonstrates that the newly developed portable reflectance confocal microscope (PRCM) offers real-time, noninvasive monitoring of wound healing processes by visualizing skin morphology in both mice and humans.
1 citations
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November 2023 in “Polymers” This review examines how incorporating various polymers and active ingredients into polyurethane dressings can enhance their properties and adaptability for better wound repair and regeneration, suggesting a promising direction for developing advanced functional dressings.
February 2009 in “Journal of The American Academy of Dermatology” The document concludes that detailed clinical descriptions of seven family cases help understand dominant dystrophic epidermolysis bullosa's symptoms and inheritance.
188 citations
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February 2023 in “International Journal of Molecular Sciences” This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.
57 citations
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December 2012 in “Molecules” This study found that mahanimbicine and a crude extract of Murraya koenigii may enhance wound healing in rats by promoting faster wound contraction and higher collagen deposition.
January 2026 in “Burns & Trauma” This study reported that NLRP3 plays complex roles in wound healing by initially promoting inflammation and delaying repair, but later enhancing structural restoration through distinct signaling pathways, highlighting its potential as a therapeutic target for controlling inflammation and regeneration phases.
July 2026 in “Methods and Protocols” In this study, researchers developed a mouse model of non-healing wounds associated with streptozotocin-induced diabetes and found that it significantly delayed regenerative processes compared to healthy controls, suggesting its relevance for preclinical testing of wound regeneration drugs.
51 citations
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July 2008 in “Dermatologic Therapy” This article proposes two new categories of cicatricial alopecia—“unstable” and “stable”—and suggests surgical excision as preferred over hair transplantation, especially for unstable cases.
20 citations
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August 2022 in “Frontiers in Immunology” This review discusses the role of fibroblasts in treating diabetic complications and wound healing, highlighting their potential as immunomodulatory factors but provides no new clinical results.
10 citations
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February 2021 in “Pharmaceutics” In this study, the novel fatty acid-conjugated tetrapeptide Palmitoyl-GDPH enhanced wound healing in rats by improving re-epithelialization and collagen deposition with minimal toxicity observed at the used dosage.
8 citations
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August 2025 in “Journal of Translational Medicine” This comprehensive review suggests that CD44 signaling plays a significant role in post-natal skin wound healing and scar formation, with potential for therapeutic approaches targeting CD44 to shift from fibrotic scarring towards regenerative healing, including wound regeneration and hair neogenesis.
January 2024 in “Authorea (Authorea)” This review examined the use of nanomaterials in different stages of wound healing, describing their mechanisms, current challenges, and potential future applications, including intelligent healing through real-time monitoring and precision regulation, to guide future research in wound treatment.
47 citations
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December 2021 in “Applied Sciences” This study demonstrated that Stellaria media extract may enhance wound healing in vitro by promoting cell migration and proliferation, with notable antioxidant and antimicrobial properties.
1 citations
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October 2025 This source describes wound healing as a complex biological process that requires precise regulation and coordination among various cells, cytokines, and signaling pathways to achieve tissue repair, although specific findings or results are not provided in the abstract.
August 2026 in “Pharmaceuticals” This review reports that biopolymer-based hydrogels show promise as wound dressings due to their biocompatibility, moisture retention, and ability to mimic the extracellular matrix, though challenges in mass production, safety, and clinical validation remain.
169 citations
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January 2020 in “Burns & Trauma” In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.