CD44 Signaling in Skin Wound Healing and Regeneration

    August 2025 in “ Journal of Translational Medicine ”
    Annie Y Guan, Yanlin Chen, Scheffer C.G. Tseng, Qing Lin
    Studysummary This comprehensive review suggests that CD44 signaling plays a significant role in post-natal skin wound healing and scar formation, with potential for therapeutic approaches targeting CD44 to shift from fibrotic scarring towards regenerative healing, including wound regeneration and hair neogenesis.
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    Research cited in this study 8

    1. Signaling by Senescent Melanocytes Hyperactivates Hair Growth Nature · 2023
    2. Proopiomelanocortin (POMC) and Psychodermatology Skin Health and Disease · 2023
    3. Extracellular Vesicles from Hair Follicle-Derived Mesenchymal Stromal Cells: Isolation, Characterization, and Therapeutic Potential for Chronic Wound Healing Stem cell research & therapy · 2022
    4. Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34+ Precursor Cells Enhances Healing with Hair Follicle Regeneration Advances in wound care · 2019
    5. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    6. Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration After Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus Journal of Investigative Dermatology · 2014
    7. Fetal Skin Wound Healing Advances in Clinical Chemistry · 2009
    8. Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism PLoS Medicine · 2006