Deletion of Adipocyte Sine Oculis Homeobox Homolog 1 Prevents Lipolysis and Attenuates Skin Fibrosis

May 2024

Nancy Wareing, Tingting Mills, Scott D. Collum, Minghua Wu, Lucy Revercomb, Rene Girard, Marka A. Lyons, Brian Skaug, Weizhen Bi, Meer A. Ali, Haniyeh Koochak, Anthony R. Flores, Yuntao Yang, W. Jim Zheng, William R. Swindell, Shervin Assassi, Harry Karmouty‐Quintana, Harry Karmouty-Quintana

Sine Oculis Homeobox Homolog 1 SIX1 dermal fibrosis systemic sclerosis SSc adipocytes dermal white adipose tissue DWAT fibrotic gene expression bleomycin SERPINE1 PAI-1 pro-fibrotic mediators

Studysummary This study suggests that targeting the increased expression of SIX1 in systemic sclerosis may be a viable strategy for addressing dermal fibrosis.

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research Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs

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This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.

research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

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This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

research Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice

136 citations , September 2019 in “Journal of Clinical Investigation”

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

research A Guide to Studying Human Dermal Adipocytes In Situ

21 citations , March 2018 in “Experimental Dermatology”

This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.

research Skin Aging: Are Adipocytes the Next Target?

70 citations , July 2016 in “Aging”

This study suggests that dermal adipocytes might play a key role in skin aging due to their transformation into fibrotic structures in chronically photo-damaged skin.

research Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis

142 citations , August 2015 in “Arthritis & Rheumatology”

This study found significant heterogeneity in transcriptome patterns among SSc patients, identifying prominent fibroinflammatory and keratin signatures that may aid in stratifying patients for targeted treatment approaches.

research Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing

238 citations , March 2013 in “Development”

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.