Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs

The document discussed the process of adipocyte-to-mesenchymal transition (AMT), which occurred in multiple organs and diseases and involved transdifferentiation through a precursor cell. This process was reversible and could be influenced by factors such as metabolic stress, myeloid cells, immune dysregulation, and pharmacological intervention. AMT was recognized as a significant process in various forms of fibrosis, and targeting it could have served as a novel approach for treating fibrosis.