Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs

September 2020 in “ Current Rheumatology Reports ”

Roberta Gonçalves Marangoni, Benjamin D. Korman, John Varga

Studysummary This review discusses the emerging role of AMT in fibrosis and suggests that targeting AMT could offer a novel approach to treatment; it reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discussed the process of adipocyte-to-mesenchymal transition (AMT), which occurred in multiple organs and diseases and involved transdifferentiation through a precursor cell. This process was reversible and could be influenced by factors such as metabolic stress, myeloid cells, immune dysregulation, and pharmacological intervention. AMT was recognized as a significant process in various forms of fibrosis, and targeting it could have served as a novel approach for treating fibrosis.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease

48 citations , June 2020 in “Current Rheumatology Reports”

This review explores the diverse roles and heterogeneity of fibroblasts across different organs, highlighting their potential involvement in both normal tissue functioning and fibrotic diseases, but reports no new experimental results.

research Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice

136 citations , September 2019 in “Journal of Clinical Investigation”

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

research Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense

49 citations , March 2019 in “Journal of Investigative Dermatology”

This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.

research Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

418 citations , January 2018 in “Journal of Investigative Dermatology”

This study identified at least four distinct fibroblast populations in adult human skin, each with unique functional properties, suggesting potential therapeutic applications for wound healing and fibrosis-related diseases.

research Fibroblast Heterogeneity: Implications for Human Disease

299 citations , January 2018 in “Journal of Clinical Investigation”

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

research Adipocyte-Myofibroblast Transition as a Possible Pathophysiological Step in Androgenetic Alopecia

18 citations , May 2017 in “Experimental Dermatology”

This article discusses a potential link between adipocyte-myofibroblast transition and androgenetic alopecia, suggesting AMT may play a role in fibrosis associated with the condition but presents no new results.

research Regeneration of Fat Cells from Myofibroblasts During Wound Healing

408 citations , January 2017 in “Science”

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

research Defining Dermal Adipose Tissue

218 citations , May 2014 in “Experimental Dermatology”

This review explores the evolution and development of skin-associated adipose tissue and proposes new nomenclature for the cells and adipose tissue underlying the reticular dermis, without reporting clinical results.