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GlossaryScleroderma (SSc)

chronic autoimmune disease causing skin and connective tissue hardening

Scleroderma, also known as systemic sclerosis, is a chronic autoimmune disease characterized by the hardening and tightening of the skin and connective tissues. It can affect not only the skin but also internal organs such as the heart, lungs, kidneys, and digestive tract, leading to a range of symptoms from mild to life-threatening. The exact cause is unknown, but it involves an overproduction of collagen, leading to fibrosis and vascular abnormalities.

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Transplantation of Bone-Marrow-Derived Mesenchymal and Epidermal Stem Cells Contribute to Wound Healing with Different Regenerative Features

research Transplantation of Bone-Marrow-Derived Mesenchymal and Epidermal Stem Cells Contribute to Wound Healing with Different Regenerative Features

36 citations, April 2013 in “Cell and Tissue Research”

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells by Intracellular Granularity

10 citations, January 2013 in “Stem Cells and Development”

Scientists identified a unique type of human skin stem cell that could help with tissue repair.

research Systemic Scleroderma and Lupus Panniculitis with Atypical Clinical Features: A Case Report and Comprehensive Review

3 citations, September 2018 in “JAAD case reports”

A Japanese man with rare skin conditions improved with hydroxychloroquine treatment.

research High Fat Diet and the Adipocyte to Myofibroblast Transition: Implications for Systemic Sclerosis Cutaneous Fibrosis

June 2024

A high fat lard diet may protect against skin fibrosis and affect hair growth.

research Dermatological Findings in Common Rheumatologic Diseases in Children

January 2019 in “Medicine Science | International Medical Journal”

Children with different rheumatologic diseases have specific skin symptoms that can help with diagnosis.

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community Something I wish I knew about hairloss 10 years ago

in Treatment 100 upvotes 1 week ago

Hair transplants can initially yield good results, but native hair is more reliable, and transplanted hair may still be lost over time. Early intervention with treatments like topical finasteride and minoxidil is recommended, but it's important to start with lower doses and manage expectations realistically.