Cell-Free Regenerative Medicine: Identifying the Best Source of Mesenchymal Stem Cells for Skin Therapy in Systemic Sclerosis

February 2025 in “ Frontiers in Cell and Developmental Biology ”

Filomena Napolitano, Valentina Giudice, Vittoria D’Esposito, Nella Prevete, Pasqualina Scala, Amato de Paulis, Carmine Selleri, Pietro Formisano, Francesca Wanda Rossi, Nunzia Montuori

mesenchymal stem cells Wharton's Jelly-derived Mesenchymal Stem Cell-Conditioned Medium systemic sclerosis skin therapy cell-free regenerative medicine WJ-MSC-CM SSc

TLDR Wharton's Jelly stem cell medium may help treat skin issues in Systemic Sclerosis.

The study evaluates the regenerative potential of mesenchymal stem cell-conditioned media (MSC-CM) from various sources for treating skin manifestations in Systemic Sclerosis (SSc). It finds that Wharton's jelly MSC-CM (WJ-MSC-CM) and bone marrow MSC-CM (BM-MSC-CM) are particularly effective due to their rich content of growth factors and cytokines. WJ-MSC-CM significantly enhances wound healing and VEGF expression in SSc fibroblasts, making it a promising therapeutic strategy. Both WJ-MSC-CM and BM-MSC-CM show potential for promoting tissue repair and immune modulation, with WJ-MSC-CM offering additional benefits such as ease of isolation and high proliferation potential. Further research is needed to standardize procedures and assess clinical efficacy.