Systemic Scleroderma and Lupus Panniculitis with Atypical Clinical Features: A Case Report and Comprehensive Review

    September 2018 in “ JAAD case reports ”
    Aaron R. Mangold, Collin M. Costello, Helen J.L. Cumsky, David J. DiCaudo, W. Leroy Griffing, Mark R. Pittelkow
    TLDR A Japanese man with rare skin conditions improved with hydroxychloroquine treatment.
    This case report and review discussed a rare co-occurrence of systemic scleroderma (SSc) and lupus erythematosus panniculitis (LEP) in a 33-year-old Japanese man. The patient presented with multiple tender, indurated subcutaneous nodules and plaques, which improved significantly with hydroxychloroquine treatment. A literature review identified only 5 similar cases, all in Japanese individuals, suggesting a potential genetic component. The study highlighted the importance of distinguishing LEP from morphea profunda and recommended antimalarial drugs as a first-line treatment for LEP in the context of SSc.
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