Systemic Scleroderma and Lupus Panniculitis with Atypical Clinical Features: A Case Report and Comprehensive Review

This case report and review discussed a rare co-occurrence of systemic scleroderma (SSc) and lupus erythematosus panniculitis (LEP) in a 33-year-old Japanese man. The patient presented with multiple tender, indurated subcutaneous nodules and plaques, which improved significantly with hydroxychloroquine treatment. A literature review identified only 5 similar cases, all in Japanese individuals, suggesting a potential genetic component. The study highlighted the importance of distinguishing LEP from morphea profunda and recommended antimalarial drugs as a first-line treatment for LEP in the context of SSc.