Systemic Scleroderma and Lupus Panniculitis with Atypical Clinical Features: A Case Report and Comprehensive Review

September 2018 in “ JAAD case reports ”

Aaron R. Mangold, Collin M. Costello, Helen J.L. Cumsky, David J. DiCaudo, W. Leroy Griffing, Mark R. Pittelkow

systemic scleroderma lupus erythematosus panniculitis hydroxychloroquine morphea profunda antimalarial drugs SSc LEP Plaquenil

TLDR A Japanese man with rare skin conditions improved with hydroxychloroquine treatment.

This case report and review discussed a rare co-occurrence of systemic scleroderma (SSc) and lupus erythematosus panniculitis (LEP) in a 33-year-old Japanese man. The patient presented with multiple tender, indurated subcutaneous nodules and plaques, which improved significantly with hydroxychloroquine treatment. A literature review identified only 5 similar cases, all in Japanese individuals, suggesting a potential genetic component. The study highlighted the importance of distinguishing LEP from morphea profunda and recommended antimalarial drugs as a first-line treatment for LEP in the context of SSc.

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research Systemic Scleroderma and Lupus Panniculitis with Atypical Clinical Features: A Case Report and Comprehensive Review

3 citations, September 2018 in “JAAD case reports”

A Japanese man with rare skin conditions improved with hydroxychloroquine treatment.