This study suggests that targeting the increased expression of SIX1 in systemic sclerosis may be a viable strategy for addressing dermal fibrosis.
April 2023 in “Journal of Investigative Dermatology” This study identified a new role for IL-4Ra-induced oxidative metabolism in wound macrophages, essential for balancing inflammatory response and promoting pro-fibrotic repair, suggesting a target for fibrosis prevention.
10 citations
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September 2021 in “The FASEB Journal” This study found that ACKR2 plays a crucial role in reducing inflammatory skin fibrosis and promoting inflammation resolution through IFN‐β production, limiting tissue scarring.
July 2025 in “International Journal of Molecular Sciences” This study found that blocking the chemokine CXCL12 in a testosterone-induced mouse model of androgenetic alopecia restored hair regeneration and reduced fibrosis and immune alterations.
23 citations
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January 2024 in “Journal of Investigative Dermatology” In this study, researchers used advanced RNA sequencing techniques to discover that communication between specific fibroblast and myeloid cell populations may play a role in acne keloidalis, and found that corticosteroid injections could significantly reduce disease activity and gene expression related to these cells.