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May 2024 in “Skin Appendage Disorders” In this case study, researchers reported that a patient with plaque alopecia areata experienced complete and sustained hair regrowth after treatment with 5-Fluorouracil and Bleomycin via microinfusion of medicines, despite initial cutaneous atrophy caused by intralesional corticosteroid therapy.
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May 2020 in “PubMed” This study found that autophagy-related gene expressions in bleomycin-induced mouse skin fibrosis initially increased and then decreased, implying autophagy activation may potentially reverse skin fibrosis.
June 2024 in “Georgetown Scientific Research Journal” This study found that intradermal bleomycin injections induced dermal fibrosis in C57BL/6 mice, evidenced by hair follicle obliteration and dermal thickening, though no significant trends in gene expression were observed, indicating the need for further research to understand the link between fibrosis and dyschromia.
January 2022 in “Dermatology Review” In this study, microneedling combined with bleomycin treatment for plantar warts improved the response time and reduced the number of treatment sessions needed, with a relapse rate similar to other injection-based methods.
January 2005 in “Linchuang pifuke zazhi” In this study, transfection of the VEGF165 gene increased hair growth and rejuvenated the atrophic dermis in a mouse model of sclerotic skin.