Efficacy of Carbazole Alkaloids, Essential Oil and Extract of Murraya Koenigii in Enhancing Subcutaneous Wound Healing in Rats

The study examined the wound healing potential of carbazole alkaloids, essential oil, and extract from Murraya koenigii in 84 rats. The extract significantly enhanced wound contraction, collagen deposition, and epithelialization, with over 50% contraction by day 14 and complete epithelialization by day 16. By day 28, collagen deposition reached 91.78%, and near-complete dermal tissue construction was observed. The extract also promoted collagen, fibroblast, and hair follicle formation while reducing inflammation, aided by its antimicrobial and antioxidant properties. Histopathological evaluations showed no cytotoxic effects, suggesting M. koenigii as a promising candidate for enhancing wound healing.