May 2019 in “Journal of Acupuncture Research” This study found that pharmacopuncture and topical application of Sebalgukhwa-san extract improved hair growth, density, and thickness in an alopecia mouse model without affecting liver function.
10 citations
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January 2023 in “Journal of Orthopaedic Surgery and Research” This study found that combining Panax notoginseng saponins with bone mesenchymal stem cells significantly enhanced diabetic cutaneous ulcer healing in rats by reducing inflammation and promoting new epidermis formation through specific molecular pathways.
31 citations
,
August 2022 in “Frontiers in Oncology” This review discusses the potential benefits of photobiomodulation for managing side effects of cancer therapy and provides specific guidelines for its use in supportive cancer care, without presenting new clinical results.
15 citations
,
September 2021 in “Journal of Clinical Medicine” This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects.
12 citations
,
October 2023 in “International Journal of Molecular Sciences” This review examined the pathological effects of mechanical pressure on human skin at the cellular level, highlighting how various skin cell types respond to pressure, potentially leading to pathological changes such as inflammation, ischemia, and impaired differentiation.
7 citations
,
August 2021 in “Heliyon” This study suggests that the herbal formulation Phyllotex™ may promote hair growth in androgenetic alopecia by enhancing cell proliferation and reducing oxidative stress and TGF-β1 expression in vitro.
1 citations
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March 2022 in “Daehanhanuihakoeji” In this study, Artemisia sieversiana extract was found to safely promote hair follicle dermal papilla cell growth and inhibit hair loss through anti-androgen, anti-inflammatory, and antioxidant effects at a cellular level.
December 2024 in “Frontiers in Pharmacology” In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.
February 2024 in “Biomedical journal of scientific & technical research” This study explored whether inositol and phytic acid, components from rice bran, could be effective and safe alternatives to minoxidil for promoting hair growth, due to concerns about minoxidil's side effects with long-term use in women. Results are not reported.
January 2022 in “Tissue & Cell” This study found that platelet-rich plasma was more effective than minoxidil in treating androgenic alopecia in rats, with the best results observed when both treatments were combined.
October 2024 in “A I Burnasyan Federal Medical Biophysical Center Clinical Bulletin” This literature review on androgenetic alopecia highlights its significant impact on patients' mental health and quality of life and discusses various treatment pathways, including topical, systemic, and surgical interventions, while emphasizing the need for continued research to develop effective therapies.
In this study, the SFE-4 extract from coffee pulp demonstrated potential effects for treating androgenetic alopecia by enhancing cell proliferation and gene expression related to hair growth pathways in vitro, using human hair follicle dermal papilla and prostate cancer cells.
48 citations
,
January 2024 in “Frontiers in Pharmacology” This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.
16 citations
,
March 2023 in “Clinical Cosmetic and Investigational Dermatology” This study demonstrated that regular use of LactoSporin cream for 10 weeks significantly reduced wrinkles and fine lines in healthy female participants, although improvements in skin elasticity and hydration were not significantly better than placebo when measured by certain instruments.
February 2026 in “International Journal of Molecular Sciences” This review discusses the potential benefits of hyperthermia in cancer therapy, combined with natural compounds, to enhance treatment efficacy and reports no new clinical results.
55 citations
,
September 2020 in “Frontiers in Bioengineering and Biotechnology” This review discusses surface engineered metal-organic frameworks for wound healing and reports no new clinical results; it highlights their potential as antibacterial agents, therapeutic delivery systems, and wound dressings.
17 citations
,
November 2021 in “Journal of Cosmetic Dermatology” This review discusses treatment options for androgenetic alopecia, highlighting the need for personalized, evidence-based approaches but reports no new clinical results.
3 citations
,
July 2024 in “Biomolecules” This paper explores how melatonin interacts with various magnetic fields, noting that it can enhance certain positive health effects or inhibit destructive processes, but may also exacerbate conditions like multiple sclerosis by intensifying inflammation.
7 citations
,
May 2018 in “Indian Journal of Pharmacology” This study found that the methanolic extract of Carthamus caeruleus roots significantly reduced inflammation, promoted wound healing, and enhanced hair growth in experimental models, supporting its traditional use in Northern Algeria as a skincare remedy.
14 citations
,
April 2021 in “Heliyon” This study found that both alcoholic and aqueous extracts of Punica granatum L. showed potential for promoting hair growth and exhibited anti-lice and antidandruff activities in a mouse model.
50 citations
,
September 1975 in “American Heart Journal” Minoxidil effectively controls blood pressure in severe cases, but may cause fluid retention and edema.
33 citations
,
April 1990 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, with better results in women.
November 2023 in “Journal of Cosmetic Dermatology” This study concluded that while both 5% topical and 1 mg oral minoxidil significantly improved hair diameter in androgenetic alopecia patients, there was no significant difference in overall effectiveness or patient satisfaction between the treatments.
1 citations
,
January 2016 in “Journal of Headache & Pain Management” This article highlights the need to consider topical minoxidil as a differential diagnosis for unexplained headache and dizziness due to its potential side effects.
August 2024 in “Cosmetics” This review discusses genetic and pharmacogenetic insights, along with RNA interference technologies, for developing personalized therapies for androgenetic alopecia, yet presents no new clinical results.
February 2025 in “Journal of Investigative Dermatology” DMG-Na may help reduce hair loss and improve hair growth, but more research is needed.
96 citations
,
October 1981 in “Drugs” Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.
37 citations
,
April 1979 in “The Journal of Clinical Pharmacology” Minoxidil effectively controls blood pressure but side effects may limit its use.
19 citations
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May 1979 in “Archives of internal medicine” Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
January 1983 in “Side effects of drugs annual” This chapter reviews adverse effects of anti-anginal and beta-blocker drugs, stating that starting a beta-blocker may temporarily affect driving ability, but it reports no new clinical findings.