Enhancing Cancer Therapy With Hyperthermia: Synergistic Effects With Natural Compounds and Conventional Treatments

Hyperthermia (HT) enhances cancer therapy by increasing the effectiveness of chemotherapy and radiotherapy through mechanisms such as impaired DNA repair, increased drug uptake, and improved tumor oxygenation. When combined with natural compounds like flavonoids and propolis, HT further boosts treatment outcomes by modulating the tumor microenvironment, inducing oxidative stress, and enhancing immune responses. These natural agents are cost-effective and reduce side effects, making HT a promising approach to cancer treatment. Despite challenges like potential damage to healthy tissues and thermotolerance, HT shows potential for improving therapeutic outcomes, especially when integrated with novel strategies like nanoparticles and thermal cycling.