Beyond DNA-Targeting in Cancer Chemotherapy: Emerging Frontiers - A Review

August 2020 in “ Current topics in medicinal chemistry ”

Simon Ngigi Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga, Martin O. Onani

TLDR New cancer treatments aim to reduce side effects and improve effectiveness.

The review discussed the limitations of traditional DNA-targeting chemotherapy, which often harmed healthy rapidly dividing cells, leading to side effects like hair loss. It highlighted the need for novel cancer treatments targeting unique cellular mechanisms in cancer cells, such as nanoparticle delivery, quantum dots, metal complexes, tumor ablation, magnetic hyperthermia, pathomics, radiomics, laser surgery, and exosomes. These emerging approaches aimed to reduce toxicity and overcome cancer resistance, with detailed comparisons of their potential benefits and drawbacks. The review underscored the importance of innovative strategies in advancing cancer treatment.

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