Search

for
Search:

Did you mean Transgenic Mouse Model?

Glossary Transgenic Mouse Model

A transgenic mouse model is a genetically modified organism that has had a foreign gene inserted into its genome, allowing researchers to study the effects of specific genes on biological processes, including hair loss and hair biology. These models are particularly relevant in the field of hair research as they can mimic human hair loss conditions, such as androgenetic alopecia or alopecia areata, providing insights into the underlying mechanisms and potential therapeutic targets. Key distinguishing characteristics of transgenic mouse models include the ability to control gene expression and the capacity to observe phenotypic changes in hair growth and follicle development in a living organism.

Related Terms

Sort by

Research

30 / 1000+ results

research Transgenic mouse models support HCR as an effector gene in the PSORS1 locus

37 citations , June 2004 in “Human molecular genetics online/Human molecular genetics”

This study suggests that the HCR risk allele within the PSORS1 locus may contribute to psoriasis susceptibility by altering gene expression related to skin structure and differentiation, although these changes alone might not result in clinical symptoms.

research Characterization of a new, inducible transgenic mouse model with GFP expression in melanocytes and their precursors

14 citations , October 2017 in “Gene Expression Patterns”

This study generated a Dct-H2BGFP mouse model that allows for effective identification and isolation of melanocytic cells in vivo, facilitating research into their molecular and biological properties.

research A transgenic mouse model to study the role of epidermal growth factor (EGF) in hair and skin development

January 2002

EGF affects hair and skin development.

research Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris

17 citations , April 2011 in “Journal of Dermatological Science”

This study reports that the transgenic expression of Dsg1 in mice rescued the severe B6-Dsg3−/− phenotype and created a syngeneic mouse model of pemphigus vulgaris, which may aid in understanding autoimmunity mechanisms.

TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia

research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia

38 citations , January 2016 in “Cell Death and Disease”

This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.

research Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions

20 citations , April 2000 in “Experimental dermatology”

This study observed that overexpression of the enzyme ODC in transgenic mice caused hair loss and skin changes similar to human papular atrichia, suggesting that ODC might be involved in a critical hair follicle function pathway.

research Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation

5 citations , July 2022 in “Radiation Research”

This study developed a mouse model to simulate chronic radiation-induced salivary dysfunction, revealing dose-dependent saliva reduction and glandular changes, which may help advance salivary regenerative therapies.

research HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion

25 citations , June 2017 in “Journal of Investigative Dermatology”

This study found that in a transgenic mouse model, β-HPV infection led to increased skin thickness and proliferation of specific keratinocyte stem cells, which may contribute to squamous cell carcinoma development.

research K6/ODC transgenic mice as a sensitive model for carcinogen identification

57 citations , July 2000 in “Toxicology Letters”

This study found that the K6/ODC transgenic mouse model is highly sensitive to identifying genotoxic carcinogens, showing 100% concordance with traditional rodent bioassays.

research Dormant tumor cells in ret transgenic mouse melanoma model and their interaction with memory T cells

January 2012 in “heiDOK (Heidelberg University)”

In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.

research G4, is a new transgenic mouse model for the polycystic ovaries syndrome

January 2019

This study presents the G4 transgenic mouse model, which suggests a direct link between polycystic ovary syndrome and the Gm10800 gene, offering a valuable tool for understanding the disease and testing treatments.

research Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis

7 citations , September 2006 in “Molecular Carcinogenesis”

This study observed that K5Cre +/+ transgenic mice develop a distinct phenotype characterized by wavy hair, curly whiskers, and an increased rate of papilloma malignant transformation.

research Tracing the Change and Contribution of Subcutaneous Adipose to Skin Expansion Using a Luciferase-Transgenic Fat Transplantation Model

4 citations , May 2023 in “Plastic & Reconstructive Surgery”

This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.

research Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model

2 citations , September 2020 in “International Journal of Molecular Sciences”

In this study, the elimination of NG2+ hair follicle stem cells during the anagen phase was associated with an aggravated sensitization phase of allergic contact dermatitis, suggesting their immunosuppressive role.

research Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review

28 citations , December 2005 in “Oncogene”

research Animal models of psoriasis—highlights and drawbacks

53 citations , June 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This review discusses the development and use of various animal models for studying psoriasis, highlighting their strengths and limitations, but reports no new experimental results.

research Experimental Models and Molecular Pathogenesis: An Integrated Review of Alopecia

January 2026 in “Dermatologic Therapy”

This review highlights a disconnect between mechanistic insights and physiological relevance in preclinical models of hair loss disorders and suggests a shift toward more human-relevant systems could enhance translational research, despite limitations in existing models like transgenic mice and xenografts.

research Animal Models of Psoriasis – What Can We Learn from Them?

127 citations , April 1999 in “Journal of Investigative Dermatology”

This review compares various rodent models that reflect aspects of psoriasis with human psoriasis and potential applications for research, reporting no new clinical findings.

research A Review of Hair Anatomy and Animal Models for Alopecia

October 2023 in “Recent Trends in Pharmaceutical Sciences and Research”

This review examines the anatomy and physiology of hair, focusing on the hair growth cycle and various types of alopecia, using animal models such as mice and rats to study the condition's pathophysiology and aid in developing new treatments.

research Alopecia areata − animal models

69 citations , July 2002 in “Clinical and Experimental Dermatology”

This review discusses rodent models of alopecia areata and highlights genetic and epigenetic factors influencing its development, but reports no new experimental results.

research A Mouse Model of Androgenetic Alopecia

42 citations , March 2010 in “Endocrinology”

This study reports the development of the first rodent model for androgenetic alopecia, demonstrating that overexpression of androgen receptors in mice delays hair regeneration and can be used to test new treatments.

research Transgenic Flash Mice for In Vivo Quantitative Monitoring of Canonical Wnt Signaling to Track Hair Follicle Cycle Dynamics

16 citations , February 2014 in “Journal of Investigative Dermatology”

This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.

research Is the “Comb Over” Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia)

3 citations , April 2010 in “Endocrinology”

This review discusses the mechanisms of androgenic alopecia and reports no new results; the development of a mouse model for further study is described.

research Transgenic HPV11-E2 protein modulates URR activity in vivo

2 citations , February 2023 in “Transgenic Research”

In this study, the presence of the HPV11-E2 protein in transgenic mice was found to increase and vary the expression of a reporter gene in hair follicle bulge regions.

research Evaluation of Animal Models Suitable for Hair Research and Regeneration

3 citations , May 2018 in “InTech eBooks”

This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.

research 921 Generation of a new rodent model of scleroderma

April 2019 in “Journal of Investigative Dermatology”

Researchers created a new mouse model for studying scleroderma.

research 132 Design of an in vitro skin 3D model mimicking a disruption of the barrier function

September 2017 in “Journal of Investigative Dermatology”

This study suggests that activating the hexosamine pathway may enhance skin homeostasis, potentially increasing hair follicle stem cells and modifying extracellular matrix components like hyaluronic acid in vitro.

research ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

research The epidermis: rising to the surface

238 citations , October 1994 in “Current opinion in genetics & development”

This article reviews the role of epidermal proteins and regulatory mechanisms in skin diseases, emphasizing recent insights but reports no new experimental results.

research The role of keratin proteins and their genes in the growth, structure and properties of hair

228 citations , January 1997 in “Birkhäuser Basel eBooks”

This article integrates existing literature on hair follicle structure and formation at the cellular and molecular level, reporting no new findings.