Transgenic HPV11-E2 Protein Modulates URR Activity In Vivo
February 2023
in “
Transgenic Research
”
TLDR The E2 protein affects gene activity in hair follicles of mice.
In a transgenic mouse model containing the URR region of HPV11, the E2 protein modulates transcription of a lacZ reporter gene, with expression occurring exclusively in the bulge region of hair follicles. Double transgenic mice expressing both the URR and HPV11-E2 protein show increased and more variable lacZ expression in the same region, indicating that E2 can both induce and repress URR activity in vivo.
