Studysummary In this study, the presence of the HPV11-E2 protein in transgenic mice was found to increase and vary the expression of a reporter gene in hair follicle bulge regions. Our plain-language summary of this paper — not a Tressless recommendation.
In a transgenic mouse model containing the URR region of HPV11, the E2 protein modulates transcription of a lacZ reporter gene, with expression occurring exclusively in the bulge region of hair follicles. Double transgenic mice expressing both the URR and HPV11-E2 protein show increased and more variable lacZ expression in the same region, indicating that E2 can both induce and repress URR activity in vivo.
5 citations
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July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” The researchers reported that applying proteolytic enzymes to mice skin negatively affected hair follicles, leading to degeneration and potential impairment of stem cells from the bulge area.
2 citations
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July 1999 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” In this study, proteolytic enzymes applied to mice skin caused severe degeneration in hair follicles, including detachment of stem cells from their niche, suggesting potential impairment of stem cell function.
9 citations
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June 1999 in “Journal of Investigative Dermatology” This study observed hair-specific transcription of a reporter gene in transgenic mice, with increased expression after dexamethasone and ultraviolet B treatment.
