TLDR The E2 protein affects gene activity in hair follicles of mice.
In a transgenic mouse model containing the URR region of HPV11, the E2 protein modulates transcription of a lacZ reporter gene, with expression occurring exclusively in the bulge region of hair follicles. Double transgenic mice expressing both the URR and HPV11-E2 protein show increased and more variable lacZ expression in the same region, indicating that E2 can both induce and repress URR activity in vivo.
2 citations,
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December 2001 in “Experimental dermatology” Mutant mice help researchers understand hair growth and related genetic factors.
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December 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
