Design of an In Vitro Skin 3D Model Mimicking a Disruption of the Barrier Function

    September 2017 in “ Journal of Investigative Dermatology ”
    Pauline Rouaud, D. Boudier, Laetitia Marchand‐Martin, K. Servaes, Sylvie Bordes, B. Closs
    TLDR Activating the hexosamine pathway can improve skin health and increase hair follicle stem cells.
    The study focused on the role of the extracellular matrix (ECM) in skin homeostasis, highlighting the importance of glycosaminoglycans (GAGs) like hyaluronic acid (HA) in cellular functions. The hexosamine pathway (HP) was shown to influence skin homeostasis by improving protein quality control and modulating ECM composition. Activation of the HP led to increased HA secretion and potentially affected the stem cell niche, increasing hair follicle stem cells in vitro. The researchers developed transgenic mice for conditional HP activation to explore molecular changes in the skin and their in vivo relevance.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 14 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Best Treatment In The Pipeline?

      in Chat  15 upvotes 4 months ago
      New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

      community Has anyone else seen this encouraging verteporfin case study?

      in Progress Pictures  36 upvotes 11 months ago
      The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

      community Tropoelastin injections + verteporfin?

      in Research/Science  12 upvotes 1 year ago
      The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

    Similar Research

    5 / 1000+ results