Animal Models of Psoriasis: Highlights and Drawbacks

June 2020 in “ The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology ”

Michael P. Schön, Veit S. Manzke, Luise Erpenbeck

psoriasis transgenic models knockout models xenotransplantation immunological reconstitution drug-induced models spontaneous mutation models rodents pathophysiology immunogenetic basis fibrosis nonhuman primates dogs pigs

Studysummary This review discusses the development and use of various animal models for studying psoriasis, highlighting their strengths and limitations, but reports no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

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This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.

research The Histopathologic Spectrum of Psoriasis

111 citations , November 2007 in “Clinics in Dermatology”

This article discusses the histologic features of psoriasis, including psoriasiform epidermal hyperplasia and neutrophilic involvement, but reports no new clinical findings.

research Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

150 citations , April 1997 in “Journal of Investigative Dermatology”

research A Polygenic Mouse Model of Psoriasiform Skin Disease in CD18-Deficient Mice

89 citations , March 1996 in “Proceedings of the National Academy of Sciences”

This study found that homozygous mutant mice with a hypomorphic CD18 mutation developed a chronic inflammatory skin disease resembling human psoriasis, potentially implicating additional genetic factors in disease susceptibility.

research Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Interleukin 6: Insights Into Its Function in Skin by Overexpression in Transgenic Mice

221 citations , June 1992 in “Proceedings of the National Academy of Sciences”

In this study, IL-6 expression in transgenic mice thickened the stratum corneum without causing increased epidermal proliferation or inflammation, suggesting it may enhance skin protection rather than directly induce inflammation.

research Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation

409 citations , May 1991 in “Genes & Development”

This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.