Characterization of Transgenic NSG-SGM3 Mouse Model of Precision Radiation-Induced Chronic Hyposalivation

    July 2022 in “ Radiation Research ”
    Syed Mohammed Musheer Aalam, Ishaq A. Viringipurampeer, Matthew C. Walb, E. Tryggestad, Chitra Priya Emperumal, Jianning Song, Xuewen Xu, Rajan Saini, Isabelle M.A. Lombaert, Jann N. Sarkaria, Joaquín J. García, Jeffrey R. Janus, Nagarajan Kannan
    TLDR The mouse model helps study and develop treatments for radiation-induced saliva reduction.
    This study developed a preclinical model using NSG-SGM3 mice to investigate radiation-induced chronic hyposalivation, a side effect in head and neck cancer patients. The model used precision ionizing radiation and measured saliva flow over 6 months, revealing significant differences based on age, sex, and radiation dose. Mice tolerated doses from 2.5 Gy to 7.5 Gy, with 5-7.5 Gy causing a ∼50% reduction in saliva flow and doses >5 Gy leading to chronic alopecia. The study found glandular shrinkage and loss of functional cells in salivary glands, mimicking human salivary hypofunction. This model aimed to support the development of regenerative therapies for salivary gland damage.
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