Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors

    July 2016 in “ Radiation Research ”
    Aviram Mizrachi, Ana P. Cotrim, Nora Katabi, James B. Mitchell, Marcel Verheij, Adriana Haimovitz‐Friedman
    TLDR Radiation damages salivary glands by harming blood vessels, but antioxidants might help protect them.
    The study investigated how radiation-induced microvascular injury contributed to salivary gland hypofunction, a common side effect in head and neck cancer patients undergoing radiotherapy. Using bovine aortic endothelial cells and mice, researchers found that radiation caused endothelial apoptosis and increased ceramide production, both mediated by reactive oxygen species (ROS). ROS scavengers like Tempol and NAC significantly reduced these effects, preserving microvessel density and partially restoring salivary flow. However, Tempol did not prevent the decrease in saliva quality. The findings suggested that targeting ROS-mediated ceramide generation could protect salivary gland function during radiotherapy. The study involved 12 glands from six mice per treatment group.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 67 results

      community 1.5 years on fin/min progress pics, thoughts would be great!

      in Progress Pictures  69 upvotes 4 years ago
      A 42-year-old male shared his 1.5-year hair regrowth progress using 1.25mg finasteride daily and regular doses of minoxidil twice a day, and recently started using the Derminator 2. He also mentioned his battle with cancer and Cushing's syndrome, which affected his weight and hair.

      community 5 month update on my all natural protocol

      in Update  8 upvotes 8 years ago
      The user updated on their all-natural hair loss protocol, which includes massages, LLLT, Ashwagandha, Supergreens mix, Vitamin D, Castor Oil + DMSO, a specific diet, and headstands. They reported some hair regrowth and improved hair quality, with plans to continue the regimen and monitor results.

      community South Korean Red Light Therapy Study

      in Research/Science  40 upvotes 3 weeks ago
      Korean scientists developed a red light therapy that reduces a hair loss marker by 92%. Users discussed the benefits and drawbacks of natural sunlight versus red light caps for hair health, with some suggesting supplements for vitamin D.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 2 years ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

    Similar Research

    5 / 1000+ results