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Glossary Laboratory Mouse

small rodent used in scientific research for genetic and disease studies

A Laboratory Mouse, also known as a Lab Mouse or Research Mouse, is a small rodent commonly used in scientific research due to its genetic, biological, and behavioral similarities to humans. These mice are often genetically modified or bred to study human diseases, including alopecia, to understand disease mechanisms and test potential treatments.

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Research

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research Essential resources and best practices for laboratory mouse research

4 citations , January 2025 in “Molecules and Cells”

This guide provides essential information for researchers working with laboratory mice, including husbandry, maintenance, ethical considerations, and resources for strains and data, emphasizing the importance of the 3Rs (replacement, reduction, and refinement) for humane research practices.

research Ultrastructure of the contrasting types of keratinization seen in the tail epidermis of the laboratory mouseMus musculus

11 citations , January 1977 in “Archives of dermatological research”

Mouse tail skin has different keratinization near hair follicles and scales.

research Skin and Adnexa of the Laboratory Mouse

3 citations , January 2004 in “Elsevier eBooks”

research Comparative regenerative biology of spiny ( Acomys cahirinus) and laboratory ( Mus musculus) mouse skin

37 citations , February 2019 in “Experimental Dermatology”

This study explored the regenerative abilities of the African spiny mouse's skin, revealing more robust wound-induced hair follicle neogenesis compared to laboratory mice and highlighting unique features of its hair and wound response.

The Expression of the Gene Aseb in the Laboratory Mouse: Sebaceous Glands

research The expression of the gene asebia in the laboratory mouse: 3. Sebaceous glands

16 citations , April 1978 in “Genetics Research”

This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.

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Learn

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learn Valproic acid

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.

learn Follistatin

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.

learn SCUBE3

What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth? No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

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Community Join

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community Is this true? It can be a major breakthrough

1008 upvotes 5 months ago

Deoxyribose sugar gel may stimulate hair regrowth similarly to minoxidil by enhancing blood supply and follicle activity. Human trials are necessary, and current products have mixed results.

community Hair Multiplication Projects in China - Promising clinical trial results on Mice

34 upvotes 1 year ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community OrganTech Aims to Regenerate Hair and Teeth, trial on Mice show positive results

86 upvotes 1 year ago

OrganTech is working on regenerating hair and teeth, with positive results in mice, but skepticism remains about progress for humans. Users express frustration over the lack of advancements in human hair loss treatments, despite ongoing research and trials.

community Stimulating existing stem cells to grow hair.

121 upvotes 3 years ago

Hair regrowth treatments, including stem cell injections, are discussed, with skepticism about their effectiveness compared to Minoxidil and finasteride. Derma stamping is mentioned as effective when used with Minoxidil, finasteride, and dutasteride.

community Fully Functional Hair Follicles Have Been Grown in The Lab For The First Time

375 upvotes 6 months ago

Scientists have successfully grown functional hair follicles in the lab, marking a significant advancement in hair regeneration research. A user shared their personal experience with hair loss treatments, including Minoxidil and Finasteride, and plans to share a detailed protocol for hair restoration.

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