April 2021 in “Sohag Medical Journal” This research suggests that superficial cryotherapy is a safe and nearly as effective alternative to topical steroids and PUVA therapy for treating alopecia areata, especially in children.
February 2026 in “Health Science Reports” In this review, the authors emphasize the importance of understanding drug chemical structures to help general physicians better manage and treat acne, although no specific results are reported.
January 2016 in “Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)” This study aims to develop three topical formulations of finasteride to reduce its side effects for treating androgenic alopecia.
May 2026 in “Rowan Digitals Works (Rowan University)” This research review identified improved outcomes in acne treatment when oral probiotics or topical probiotic-derived formulations were added to standard therapies, with probiotics reducing acne severity and enhancing safety and tolerability compared to treatments such as 2.5% Benzoyl Peroxide and Doxycycline.
39 citations
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April 2011 in “Recent Patents on Drug Delivery & Formulation” This review discusses various applications of nanoemulsions in drug delivery and reports no new clinical results; it highlights the patents that cover these applications.
4 citations
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January 2017 in “Indian Dermatology Online Journal” This case study describes severe hypertrichosis in a 3-year-old with alopecia areata after unsupervised use of high-dose topical minoxidil, highlighting the need to avoid such practices in children.
1 citations
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July 2005 in “Drugs and the pharmaceutical sciences” Targeting drugs to hair follicles can treat skin conditions, but reaching deep follicle areas is hard and needs more research.
1 citations
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July 2005 in “CRC Press eBooks” This paper discusses topical drug delivery targeting the pilosebaceous unit for skin diseases and cosmetic purposes, emphasizing formulation choice and drug physicochemical properties but reports no new findings.
August 2025 in “South African Journal of Botany” This study found that among various polyherbal hair oil formulations using indigenous Bangladeshi plants, Formulation B was most effective, displaying strong antimicrobial activity and promoting hair regrowth in rabbits, surpassing the standard 2% minoxidil treatment, while also being safe for topical use.
59 citations
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September 2008 in “Journal of Burn Care & Research” This study found that a new topical nitric oxide gel significantly accelerated burn wound healing in mice by enhancing re-epithelialization, hair follicle regeneration, collagen deposition, and angiogenesis compared to controls.
32 citations
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May 1995 in “Contact Dermatitis” This article reviews previous cases and reports of allergic contact dermatitis from minoxidil but does not provide new clinical findings.
1 citations
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April 2018 in “Journal of Investigative Dermatology” This study found that FZD2 is crucial for hair follicle formation and postnatal growth in mice and has a novel role in regulating early epidermal development, including stratification and cornification.
April 2021 in “Journal of Investigative Dermatology” This study found that skin bacteria promote regeneration in wound-induced hair follicle neogenesis, suggesting a role for IL-1β signaling and challenging the belief that infection inhibits healing.
This review discusses the unique characteristics and possible pathophysiology of spiny keratoderma, reporting no new clinical results, but suggests that some therapies might alleviate symptoms.
May 2012 in “Scientific American” Blocking a compound called prostaglandin D₂ might help treat hair loss.
67 citations
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May 2007 in “Journal of Cosmetic Dermatology” This study found that topical formulations including extracts from Cuscuta reflexa, Citrullus colocynthis, and Eclipta alba significantly accelerated hair growth initiation and completion in rats, indicating potential benefits for treating alopecia.
In this study, a novel liposomal peptide formulation significantly enhanced hair growth in mice compared to minoxidil, but results on human tissue penetration were inconclusive, suggesting further research is needed for translation to human use.
July 2026 in “Expert Review of Clinical Immunology” This review highlights that alopecia areata is characterized by three immune endotypes, and while JAK inhibitors offer temporary control, upcoming multi-omics diagnostics and immune reprogramming strategies may achieve longer-lasting remission, according to this analysis.
18 citations
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April 1998 in “MIT Press eBooks” This study found that topical application of N,N-dimethylglycine sodium salt increased dermal blood flow and velocity in human subjects, likely through its effects on endothelial cells and NO-dependent vasodilation.
August 2024 in “Journal of Cosmetic Dermatology” This study explored the effectiveness of injectable treatments for androgenetic alopecia, finding that dutasteride and growth factor formulations achieved clinically significant results compared to controls like saline and topical minoxidil, within selected trials from 2000 to 2023.
This review discusses the potential of using sustained release systems to increase the effectiveness and reduce side effects of 17-alpha-estradiol in alopecia treatment and reports no clinical results.
July 2026 in “Anais Brasileiros de Dermatologia” This research observed that nanocarrier formulations of minoxidil improve follicular targeting and hair-growth outcomes in experimental settings, but their clinical efficacy and safety for treating androgenetic alopecia in patients remain unverified, necessitating further randomized clinical trials.
56 citations
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January 2007 in “Pharmaceutical Development and Technology” This study found that finasteride-loaded liposomal formulations achieved significantly higher skin permeation and deposition compared to conventional gels and solutions, suggesting potential for effective topical application.
22 citations
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March 2020 in “Cosmetics” This review discusses the potential of nanotechnology-based formulations for delivering topical minoxidil to improve hair loss treatment outcomes and reports no new clinical results, urging further research into their benefits and safety considerations.
September 2025 in “Frontiers in Pharmacology” This study found that the meropenem-loaded spanlastic formulation showed strong potential as an effective topical therapy for bacterial skin infections in non-diabetic mice, demonstrating superior therapeutic activity and wound healing compared to free meropenem.
December 2024 in “Chinese Chemical Letters” This study found that using hollow mesoporous silica nanoparticles as carriers in a topical finasteride formulation significantly enhanced drug retention and hair regrowth in an AGA mouse model, suggesting a promising approach for treating androgenetic alopecia with reduced side effects.
October 2024 in “Journal of Advanced Pharmaceutical Technology amp Research” This study found that nanoparticulate trigonelline formulations significantly improved hair length and density in rats with induced alopecia compared to controls and commercial hair oil, though it was not more effective than minoxidil after 30 days.
November 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found that both oral and topical formulations of VISPOTM, a saw palmetto oil, significantly reduced hair fall and increased hair density in subjects with androgenetic alopecia, with no serious adverse effects observed.
May 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review examines recent advancements in topical formulations for alopecia treatment, but it reports no new clinical results, emphasizing potential strategies to enhance drug delivery to the scalp.
1 citations
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February 2017 in “Journal of pharmacology & clinical research” This study found that topical gel formulations containing extracts of Eclipta alba and Lippia nodiflora significantly increased hair growth in black mice over 30 days, with a combination of both extracts showing greater effectiveness than either alone.