Impact of Formulation Design and Lyophilisation on the Physicochemical Characteristics of Finasteride Nanosystems

    February 2023 in “ Journal of Microencapsulation ”
    Malik Muhammad Irfan, Shefaat Ullah Shah, Kifayat Ullah Shah, Nicolas Anton, Idoux-Gillet Ysia, Guillaume Conzatti, Kifayat Ullah Shah, Perennes Elise, Thierry Vandamme
    TLDR The finasteride nanosystem with trehalose is stable and effective for topical hair loss treatment.
    The study aimed to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery, focusing on the effects of formulation design and lyophilisation. Using ultrasonication, the FNS-NS was created and tested with two cryoprotectants. The resulting lyophilised FNS-NS had a spherical shape, particle sizes between 188.6 nm and 298.7 nm, low PDI values, and a zeta potential from -38.3 to +53.3 mV. Confocal laser microscopy showed higher cellular internalisation for undecorated FNS-NS compared to chitosan-decorated ones. The system remained stable for 90 days under proper storage, and the FNS-NS with 15% trehalose showed promising attributes for treating androgenic alopecia through topical delivery.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Hairline stable but diffuse thinning with topical fin+min

      in Finasteride  230 upvotes 1 day ago
      The user experienced stable hairline but diffuse thinning after switching from oral finasteride to a topical solution of minoxidil and finasteride. They are concerned about the effectiveness of the topical treatment and are considering other options due to a recent decline in hair density.

      community 5 Months Post-Finasteride Shed: No Regrowth and Worse Hair Volume

      in Finasteride  106 upvotes 1 week ago
      The user experienced hair loss and used a topical minoxidil and finasteride solution, which initially halted hair fall and increased thickness. After switching to oral finasteride, they experienced significant shedding without regrowth, leaving them worse off than before.

      community Switching generic brands fin 1mg

      in Finasteride  1 upvotes 2 weeks ago
      The user noticed a slight loss of progress after switching to Milpharm finasteride 1mg and is considering switching to Accord finasteride. They seek advice on whether to continue with Milpharm or switch brands.

    Related Research

    2 / 2 results