Impact of Formulation Design and Lyophilisation on the Physicochemical Characteristics of Finasteride Nanosystems

February 2023 in “ Journal of Microencapsulation ”

Malik Muhammad Irfan, Shefaat Ullah Shah, Kifayat Ullah Shah, Nicolas Anton, Idoux-Gillet Ysia, Guillaume Conzatti, Kifayat Ullah Shah, Perennes Elise, Thierry Vandamme

finasteride nanosystem lyophilisation ultrasonication cryoprotectants chitosan trehalose androgenic alopecia topical delivery Propecia

TLDR The finasteride nanosystem with trehalose is stable and effective for topical hair loss treatment.

The study aimed to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery, focusing on the effects of formulation design and lyophilisation. Using ultrasonication, the FNS-NS was created and tested with two cryoprotectants. The resulting lyophilised FNS-NS had a spherical shape, particle sizes between 188.6 nm and 298.7 nm, low PDI values, and a zeta potential from -38.3 to +53.3 mV. Confocal laser microscopy showed higher cellular internalisation for undecorated FNS-NS compared to chitosan-decorated ones. The system remained stable for 90 days under proper storage, and the FNS-NS with 15% trehalose showed promising attributes for treating androgenic alopecia through topical delivery.

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