24 citations
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November 2015 in “Frontiers in Genetics” This review discusses the development and potential therapeutic effects of nitroxide small molecule agents for age-related macular degeneration and cardiovascular disease, but reports no new clinical results.
20 citations
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January 2018 in “Expert opinion on emerging drugs” This review discusses the potential of Janus Kinase inhibitors for treating alopecia areata and other forms of alopecia, highlighting the need for further research on their long-term safety and optimal formulation.
9 citations
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May 2020 in “Journal of Pharmaceutical and Biomedical Analysis” This study developed an efficient LC-MS bioanalytical method to simultaneously quantify minoxidil sulphate and latanoprost in skin layers, supporting the formulation of topical treatments for androgenic alopecia.
5 citations
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August 2014 in “Pharmaceutical Development and Technology” In this study, the researchers reported that while both propylene glycol and sodium lauryl sulfate enhanced finasteride's skin deposition, ethanol was the only effective enhancer of finasteride's permeation through the skin.
4 citations
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February 2021 in “Journal of Pharmaceutical Sciences” This study suggests that the developed PBPK model effectively predicts pharmacokinetic and pharmacodynamic profiles of topical finasteride and minoxidil on the scalp, indicating potential broader applicability for other formulations.
3 citations
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June 2022 in “Dermatology and therapy” This case report found that a novel botanical treatment halted disease progression and promoted hair regrowth in four patients with lichen planopilaris, indicating potential for use as a safe alternative therapy.
3 citations
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June 2023 in “Journal of cosmetic dermatology” This study found that a topical cream containing CBD and EPA reduced signs of extrinsic skin aging, including wrinkle volume and skin elasticity, in clinical and laboratory settings.
2 citations
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October 2021 in “Exploration of targeted anti-tumor therapy” This review describes oncotherapy-induced alopecia in patients receiving hormone therapy for hormone-receptor-positive breast cancer and concludes that topical hormones should not be used due to oncogenic potential.
2 citations
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August 2020 in “Chemical and Pharmaceutical Bulletin” This study found that rubbing increased caffeine permeation into skin primarily via hair follicles, especially when applied against the natural hair direction.
1 citations
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January 2023 in “Portuguese Journal of Dermatology and Venereology” This review covers the use of JAK inhibitors in treating various dermatological conditions, emphasizing their potential while noting ongoing safety concerns with oral treatments; no new clinical results are provided.
1 citations
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October 2017 This study found that topical gel containing ethanolic extract of Peperomia pellucida increased hair length in rabbits, but did not significantly impact hair mass compared to control treatments.
July 2026 in “International Journal of Drug Delivery Technology” This study evaluated a Piper betle leaf emulgel for topical use and found it to have good stability, non-irritant properties, and significant hair growth activity in albino mice, suggesting its potential for dermatological and hair growth applications.
September 2025 in “Polymer Korea” In this study, a parsley-derived n-hexane fraction formulated into a coconut oil-based nanoemulsion demonstrated significant hair regrowth comparable to 3% minoxidil, with near-complete coverage by day 17, suggesting potential as a topical hair growth treatment.
July 2024 in “Journal of Controlled Release” In this study, researchers developed topical tofacitinib-loaded cationic lipid nanoparticles, which improved absorption and targeted hair follicles in an ex vivo pig ear model, showing promise in treating alopecia areata by reducing symptoms through the JAK/STAT pathway.
This study found that topical finasteride was absorbed into the bloodstream to a minimal extent in male rats, even with repeated applications, suggesting low systemic exposure.
In this study, imaging techniques showed that nanostructured lipid carrier formulations distributed ascorbic acid more effectively across skin layers compared to conventional cream formulations, suggesting a better method for skin permeation.
This literature review suggests that Cyperus rotundus L extract is a promising natural agent for promoting hair growth due to its bioactive compounds and mechanisms of action, but emphasizes the need for further human clinical trials to confirm its safety and effectiveness.
June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This literature review suggests that Cyperus rotundus L extract shows promise as a natural hair growth agent due to its bioactive compounds and mechanisms that stimulate hair growth, although more human clinical trials are needed to confirm its safety and efficacy.
May 2024 in “Journal of medicinal food” This review highlights jojoba oil's unique composition and its growing therapeutic applications, noting its antioxidant, anti-acne, antidiabetic, and antibacterial properties, as well as its use in various pharmaceutical formulations.
April 2024 in “Frontiers in pharmacology” This study compared JAK inhibitors for moderate-to-severe alopecia areata and found brepocitinib 30mg and deuruxolitinib 12mg to be most effective, though deuruxolitinib may cause more adverse events. Further research is needed for long-term efficacy and safety.
November 2005 in “CRC Press eBooks” This article reviews the development and challenges of skin penetration enhancers, highlighting their limitations in compatibility and safety, and reports no new clinical findings.
March 2026 in “Asian Journal of Medical Sciences” In a prospective observational study conducted in India, most adults with alopecia experienced quality of life impairment in the minimal-to-moderate range, with androgenetic alopecia being the most common subtype and minoxidil frequently prescribed, as reported by the researchers.
November 2025 in “Open Repository of the University of Porto (University of Porto)” This report reviews a pharmacy internship experience, presenting activities and two scientific topics, but does not report new research findings.
August 2021 in “Institutional Repositories DataBase (IRDB)” This study found that rubbing the skin increased caffeine permeation significantly, while rhododendrol showed no enhancement from rubbing, likely due to different distribution patterns in the skin layers.
August 2020 in “Revista de chimie” This article discusses the potential therapeutic applications of topical nitroglycerin formulations in various medical conditions, but it reports no new clinical results.
This study found that ethanolic plant extract of Peperomia pellucida increased hair length in rabbits in a dose-dependent manner but did not significantly affect hair mass compared to controls.
55 citations
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January 2002 in “Journal of liposome research” This research explores developing liposomal formulations to enhance the delivery of difficult-to-absorb agents directly to hair follicles and sebaceous glands, with minoxidil and plasmid DNA as study molecules.
4 citations
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January 2016 in “Elsevier eBooks” This chapter reviews different animal models for evaluating wound healing treatments and provides no new experimental results.
June 2017 in “Journal of The American Academy of Dermatology” The new treatment was safe and may effectively treat male pattern hair loss.
30 citations
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December 1972 in “Archives of dermatology” This report examines efforts to enhance the efficacy of topical steroids for alopecia areata using penetration-enhancing vehicles and exceptionally high concentrations, noting systemic steroids often lead to relapses and toxicity.