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Glossary Topical Antiandrogens

medications applied to skin to block androgen effects locally

Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

49 citations , January 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that the topically applied non-steroidal antiandrogen RU 58841 may reduce androgen-dependent skin conditions in a hamster model with minimal systemic effects.

research Reversal of androgenetic alopecia by topical ketoconzole: Relevance of anti-androgenic activity

38 citations , September 2006 in “Journal of Dermatological Science”

This study evaluated the effect of 2% ketoconazole lotion for androgenetic alopecia, but the results regarding its effectiveness on clinical appearance remained unclear.

research New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice

37 citations , January 2000 in “International Journal of Pharmaceutics”

In a study using human scalp skin grafts on SCID mice, topical flutamide and finasteride significantly improved hair growth in male-pattern baldness compared to placebo, with flutamide showing superior results to finasteride.

research Topical Antiandrogens

11 citations , January 1985 in “Archives of Dermatology”

This article discusses the complex interaction between androgens and the skin, highlighting elevated androgen levels in women with hirsutism, female-pattern hair loss, and acne, but reports no new clinical results.

research Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy

August 2022 in “Journal of Pakistan Association of Dermatologists”

In this study, the application of topical 1% spironolactone in patients with androgenetic alopecia significantly increased hair count and thickness in females and increased hair count in males, though not all hair types showed significant changes.

research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

9 citations , January 2017 in “Organic Process Research & Development”

This article describes the efficient synthesis of (S)-N-(2-bromo-6-methoxypyridin-4-yl)-2-hydroxy-2,4-dimethylpentanamide, a novel topical antiandrogen, with high purity and enantiomeric excess but reports no pharmacological results.

research Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris

7 citations , December 2019 in “American Journal of Clinical Dermatology”

This review discusses the potential efficacy of topical antiandrogen therapies for treating androgenetic alopecia and acne vulgaris, finding promising results but highlighting the need for more comprehensive studies.

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

April 2012 in “Journal of the American Academy of Dermatology”

Clofazimine may be effective for treating ashy dermatosis.

research Topical antiandrogens in the treatment of male-pattern baldness

10 citations , October 1988 in “Clinics in dermatology”

This review discusses the potential of antiandrogens for androgen-induced baldness in men and women but reports no new clinical findings, emphasizing the need for further research on long-term risks and efficacy.

research Topical antiandrogens. What use in dermatology?

5 citations , January 1985 in “Archives of Dermatology”

This article reviews the complex relationship between androgenic hormones and skin disorders, emphasizing the need for further innovative research to understand varying skin responses, but it reports no new findings.

research Clascoterone: a new topical antiandrogen agent.

February 2025 in “Prospects in Pharmaceutical Sciences”

This source reports that clascoterone cream, a topical androgen receptor inhibitor, has shown effectiveness in treating facial acne vulgaris in patients 12 and older, with clinical trials indicating a favorable safety profile compared to systemic treatments, and potential for broader dermatological applications.

research Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster

26 citations , January 1987 in “Archives of Dermatology”

In this study, topical minoxidil did not show an antiandrogenic effect on androgen-dependent cutaneous structures in the golden Syrian hamster, suggesting it likely does not have this role in humans either.

research 0951 Breezula, a clinical stage topical anti-androgen, promotes dermal papilla inductivity and reduces IL-6 secretion in balding skin samples ex vivo

July 2025 in “Journal of Investigative Dermatology”

This study suggests that Breezula® and Minoxidil both enhance hair growth in male pattern hair loss by promoting keratinocyte proliferation, with Breezula® potentially more potent in reducing the hair growth inhibitor IL-6.

research Anti-androgen therapy in dermatology: a review

5 citations , December 1979 in “Clinical and Experimental Dermatology”

Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

research Pharmacology of Anti-androgens in the Skin

1 citations , January 1989 in “Handbook of experimental pharmacology”

This article reviews the use of anti-androgens for dermatological conditions linked to androgen involvement and reports encouraging clinical experiences in females, with use in males limited to specific conditions due to toxicity concerns.

research Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies

May 2025 in “Journal of the American Academy of Dermatology”

This review highlights the available and investigational anti-androgen treatments for female pattern hair loss in the US, noting their limitations and the potential for fewer systemic side effects with topical options compared to oral medications.

research Clinical applications of antiandrogens

29 citations , October 1988 in “Journal of Steroid Biochemistry”

This review discusses the use of antiandrogens for various conditions like prostate cancer and highlights their potential benefits in remission rates and symptom improvement, but it reports no new clinical results.

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase

5 citations , January 2021 in “Biomedicine & Pharmacotherapy”

This study suggests that policosanol may prevent androgenetic alopecia in mice by regulating hormone levels and suppressing premature hair follicle entry into the regression phase.

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

December 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

This review reports that anti-androgens, often combined with contraception, are supported for managing PCOS symptoms related to high androgen levels, but uncertainties remain about long-term safety and metabolic effects, indicating a need for future research on various treatment approaches.

research Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS)

December 2025 in “Zenodo (CERN European Organization for Nuclear Research)”

This review addresses the use of anti-androgens in managing symptoms of polycystic ovary syndrome, noting both their clinical effectiveness and associated safety concerns, while highlighting the need for more research into their long-term safety and metabolic effects.

research Substances declared as active ingredients in topical anti-hair loss products – a review of the evidence for their effectiveness in light of clinical studies

June 2026 in “Homo Politicus (Academy of Humanities and Economics in Lodz)”

The effectiveness of ingredients in anti-hair loss products varies, and clinical trials are crucial to determine their success.

research Topical Melatonin in Androgenetic Alopecia: Mechanisms of Action and Current Clinical Evidence

September 2026 in “Journal of Independent Medicine”

This review discusses the potential benefits of topical melatonin for androgenetic alopecia, highlighting its mechanisms and safety profile, but reports no definitive clinical results, calling for further trials.

research Percutaneous absorption of a new antiandrogen included in liposomes or in solution

20 citations , December 1995 in “International Journal of Pharmaceutics”

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

research Antiandrogen Therapy for Female-Pattern Hair Loss

January 2005 in “NEJM Journal Watch”

This article discusses treatments for female-pattern hair loss, such as topical minoxidil and antiandrogens like spironolactone, and reports no new clinical results.

research Minoxidil e óleo essencial de alecrim: proposta de solução tópica para alopecia androgenética

May 2026 in “Revista Ensaios Pioneiros”

This study developed and evaluated topical formulations containing 5% minoxidil and 1% rosemary essential oil for androgenetic alopecia treatment, finding them physically and chemically suitable, but noted that further stability tests and clinical trials are needed to confirm therapeutic efficacy and safety.

research 508 Hair follicle rejuvenation is induced by topical minoxidil administration in a humanized mouse model of androgenetic alopecia

November 2024 in “Journal of Investigative Dermatology”

Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.

research Melatonin and hair physiology: reasons and clinical efficacy data as a topical treatment of androgenic alopecia

March 2014 in “Medicina cutánea ibero-latino-americana”

This review discusses the role of melatonin in skin and hair physiology, highlighting clinical evidence for its potential benefits in treating androgenetic alopecia, but does not report new results.

research Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments

March 2026 in “Preprints.org”

This study reviewed evidence for six minimally invasive treatments for androgenetic alopecia, finding consistent support for platelet-rich plasma and topical finasteride, while other options like microneedling and intradermal dutasteride showed promise but need further and standardized research.

research Guidelines based management of androgenetic alopecia

January 2014 in “Cosmoderma”

This review examines the effectiveness of current treatments for androgenetic alopecia, offering plastic surgeons evidence-based guidance for choosing safe and effective options, but reports no new results.