Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome

    December 2025 in “ Zenodo (CERN European Organization for Nuclear Research) ”
    J. S. Venkatesh, Dr. Santosh Uttangi, Abhila B, Abhishek S*, Aksa Rajan, K Parvati
    Image of study
    TLDR Anti-androgens help manage PCOS symptoms like excess hair and acne.
    This review article discusses the role of anti-androgens (AAs) in managing symptoms of polycystic ovary syndrome (PCOS), such as hirsutism and acne, which are caused by high androgen levels. Common AAs include spironolactone, flutamide, finasteride, and cyproterone acetate, often used with effective contraception to prevent pregnancy. The article examines the mechanisms, clinical effectiveness, safety concerns, and guidelines for these treatments, highlighting the need for further research on long-term safety, metabolic effects, and direct comparisons among different AAs. Future studies aim to improve metabolic health, reduce long-term cardiovascular and metabolic risks, and enhance ovulation rates. Additionally, there is interest in combination treatments for severe hair loss, safe use in adolescents, personalized treatments based on genetics, and new topical forms to minimize systemic risks. Long-term management of persistent hirsutism is also a significant focus.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  55 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community C’est terrible - at my wits end

      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  12 upvotes 3 months ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

      community Why balding gets worse in every generation?

      in Chat  81 upvotes 1 year ago
      Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

      community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

      in Transgender  2257 upvotes 5 months ago
      A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

    Similar Research

    6 / 1000+ results