Breezula, A Clinical Stage Topical Anti-Androgen, Promotes Dermal Papilla Inductivity And Reduces IL-6 Secretion In Balding Skin Samples Ex Vivo

    July 2025 in “ Journal of Investigative Dermatology ”
    A. Le Riche, P. Pallavi, Mara Gerloni, Gordon Alton, J. Edelkamp, Marta Bertolini
    From the encyclopedia
    Clascoterone →

    a novel topical treatment that inhibits DHT on androgen receptors

    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    Studysummary This study suggests that Breezula® and Minoxidil both enhance hair growth in male pattern hair loss by promoting keratinocyte proliferation, with Breezula® potentially more potent in reducing the hair growth inhibitor IL-6.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study investigates the efficacy of Breezula® (clascoterone 5% solution) compared to Minoxidil (5%) in treating male pattern hair loss (MPHL) using scalp biopsies from 5 patients. Both treatments enhanced alkaline phosphatase (AP) activity and hair matrix (HM) keratinocyte proliferation, which are associated with hair growth. Notably, Breezula® also reduced IL-6 secretion, a hair growth inhibitor, suggesting it may be more potent than Minoxidil in promoting hair growth. These findings indicate that Breezula® could restore dermal papilla (DP) inductivity and support hair growth, meriting further research.
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