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Tenascin is present in normal skin and certain skin tumors but not in sebaceous glands or their tumors.

This study identified FP-1 as a highly specific extracellular matrix protein in follicular papilla cells, which may play a role in hair growth regulation during specific hair cycle phases.

This study reveals that transglutaminase activity is widespread in integumentary structures of mammals and birds, suggesting it plays a significant role in the cornification of hard skin appendages like nails and feathers.

This study found that intermediate filaments and matrix proteins in presumptive hair shaft cells are synthesized sequentially, identifying a new polypeptide component that changes during hair cell differentiation.

CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.

In this study, mesenchymal stem cell therapy improved erectile function in a rat model of diabetes-associated erectile dysfunction, and identified 15 hub genes potentially involved in the condition's development.

This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.

This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

This study revealed that BMP5 in onychofibroblasts may play a key role in the differentiation of nail matrix keratinocytes, highlighting transcriptional similarities between nail and hair structures.

In this study, researchers found that inhibiting YAP signaling in skin wounds leads to regenerative repair with active Trps1 and Wnt signaling, contrasting the typical fibrotic scarring process.

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.

This review examines the role of epidermal stem cells in wound healing, discussing their characteristics and mechanisms, but does not report new clinical results.

This review discusses mammalian models of epimorphic regeneration to define a vertebrate regeneration blastema, concluding that regenerative failure likely stems from cellular responses to the microenvironment after injury, not progenitor cell availability, and calls for targeted modification studies in mammals to advance human regeneration.

This study found that the CDK4/6 inhibitor palbociclib may protect human hair follicles from the damaging effects of taxane chemotherapy by inducing G1 arrest in stem/progenitor cells.

In this study, UVB irradiation of organ-cultured human anagen hair follicles in vitro reduced hair elongation and increased cell death, affecting hair growth and regulatory processes.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

This study found that Gelatinase A activity is linked to the absence of type VII collagen during human fetal skin development, indicating its role in remodeling the basement membrane zone.

This study found that mesenchymal progenitor cells from human hair roots seeded onto polymer scaffolds stimulated the production of mineralized proteins, enhancing bone-like structures, with optimal results at a pore size of 35 µm.

This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

This study demonstrated that hyaluronan gel is a promising biomaterial for 3-D in vitro culture of mouse ovarian follicles, supporting the production of fertilizable metaphase II oocytes.

In this study, silver oxide-based nanoparticles were used to ionize analytes and detect specific target molecules through adduct formation with silver isotopes, facilitating signal correlation with these molecules.

This review summarizes the mechanisms of mesenchymal stem cell-mediated wound healing and highlights engineering strategies that enhance therapeutic outcomes, but it reports no new clinical results.

In this study, mouse models of 22q11.2 deletion syndrome showed that growth issues in small embryonic thymuses were linked to mesenchymal cells, which could be corrected by substituting with normal mesenchyme.

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.

In this study, the researchers developed a hydrogel mimicking the fetal environment that significantly accelerated wound healing and hair follicle regeneration in vivo, with over 94% wound closure in 14 days, surpassing hydrogels lacking certain additives.

In this study, NuMA's microtubule-binding domain was found to be crucial for correct spindle orientation and skin differentiation, with its loss leading to neonatal lethality in mice.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.

This study identified lymphatic vessels as crucial components of the hair follicle stem cell niche, coordinating connections and contributing to hair follicle regeneration in mice.

This study presented cases of severe and permanent nail changes resembling lichen planus in patients with chilblain lupus erythematosus, suggesting a unique pattern related to cold exposure rather than typical histopathology findings.