Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma and Pilomatrix Carcinoma

October 2016 in “ Journal of dermatological science ”

Gaku Tsuji, Takamichi Ito, Takeshi Nakahara, Chikage Mitoma, Akiko Hachiya, Masaki Takao, Makiko Nakahara, Masutaka Furue, Hiroshi Uchi

OVOL1 OVOL2 zinc finger transcription factors hair follicle differentiation tumorigenesis inner root sheath matrix cells pilomatricoma pilomatrix carcinoma ketoconazole hair growth stimulant hair follicle hair growth

TLDR The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.

The study investigated the roles of OVOL1 and OVOL2, genes encoding zinc finger transcription factors, in hair follicle differentiation and tumorigenesis. OVOL1 was found to be expressed in the inner root sheath of hair follicles, while OVOL2 was expressed in matrix cells, pilomatricoma, and pilomatrix carcinoma. OVOL1 negatively regulated OVOL2 expression, and ketoconazole, a hair growth stimulant, increased OVOL1 expression without affecting OVOL2. The findings suggested that the OVOL1-OVOL2 axis played a significant role in hair follicle differentiation and could serve as markers for diagnosing pilomatricoma and pilomatrix carcinoma.

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Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma and Pilomatrix Carcinoma

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