Bone Marrow-Derived Vasculogenesis Leads to Scarless Regeneration in Deep Wounds With Periosteal Defects

The study presents a novel approach for regenerating tissue in deep skin wounds with periosteal defects, which are often difficult to heal and result in scarring. The researchers used gelatin sponges (GS) as scaffolds in rat models and found that these sponges enabled bone marrow-derived cells (BMDCs) to create a vascular niche, which is essential for the regeneration of various tissues including periosteum, skin, and skin appendages like hair follicles. This method led to scarless healing and the reformation of complex tissues, suggesting that the microenvironment provided by GS is key to promoting the involvement of BMDCs in tissue regeneration.