April 2026 in “Applied Materials Today” This study introduced a pH-responsive polymeric wound dressing that enhances healing in chronic wounds by changing shape and drug delivery based on wound pH, achieving a 94.88% healing rate in diabetic mice by day 14.
November 2025 in “Communications Materials” This research demonstrated that transforming pomelo peel into expanded sponges and carbonized aerogels can accelerate hemostasis and enhance healing in diabetic wounds while eradicating bacterial biofilms, offering an eco-friendly solution for wound care from agricultural waste.
October 2023 in “Sovremennye tehnologii v medicine” This research found that LSE transplantation positively affects wound healing by promoting granulation tissue growth and minimizing cosmetic defects in ischemic non-healing wounds during preclinical studies. Additionally, the proposed smoothing coefficient helps assess the degree of wound bed filling with developing tissue.
This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study evaluated petroleum jelly-based bioactive glass ointments with varying copper concentrations for wound healing in chronic wound models, finding that the 3 wt% copper formulation significantly improved healing by enhancing tissue regeneration, vascularization, and antibacterial protection compared to controls.
February 2024 in “Advanced Science” This study highlights that a novel radially aligned nanofiber scaffold with dual growth factor gradients significantly enhances wound healing, promoting cell migration, epidermal regeneration, and angiogenesis, ultimately leading to improved wound closure, immune regulation, and tissue remodeling compared to other groups.
328 citations
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November 2020 in “Nature Materials” This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.
2 citations
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September 2018 in “Tissue Engineering Part A” This study found that injecting xeno-free, three-dimensional cell masses from human adipose-derived stem cells improved blood perfusion and preserved limb function in mice without causing tumors or toxicity, suggesting potential for treating severe ischemic diseases.
1 citations
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January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.
1 citations
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January 2012 in “OhioLink ETD Center (Ohio Library and Information Network)” This study demonstrates that trichogenic dermal papilla cells are crucial for hair regeneration in engineered skin substitutes, with adult murine cells showing higher activity than adult human cells.
1 citations
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December 2006 in “Burns” New therapies for burn wounds show promise in reducing pain, infection risk, and improving healing and physical outcomes.
September 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study mapped the development of the human pilosebaceous unit in prenatal scalp skin using multi-modal analysis, finding that epithelial-mesenchymal interactions guide cellular fate and validated tissue-patterning through a hair-bearing skin organoid model.
November 2025 in “Bioactive Materials” In this study, researchers developed a DNA/GelMA-based cryogel platform that uses phototherapy to combat MRSA infection and promote scarless wound healing, showing enhanced bactericidal activity, tissue regeneration, and anti-inflammatory effects in vivo, suggesting a promising approach for treating infected skin wounds.
November 2025 in “Undersea and Hyperbaric Medicine” This case report observed that a patient experienced worsening alopecia and scarring after medical ozone therapy, with subsequent improvement following surgical intervention and systemic hyperbaric oxygenation.
June 2023 in “Research Square (Research Square)” This study found that polycaprolactone (PCL) in facial fillers led to more cell proliferation and vascular activity than hyaluronic acid (HA) in Wistar rats, suggesting enhanced tissue regeneration effects with PCL.
June 2023 in “Juan Cuevas eBooks” This volume is part of a series intended to educate plastic and reconstructive surgeons, residents, and other medical professionals, but the abstract does not report specific research findings.
January 2020 in “eScholarship (California Digital Library)” This study used multi-scale hybrid models to explore how signaling factors affect skin wound healing and embryo development, suggesting that different levels of fibrin clot density influence scar formation.
August 2017 in “Companion animal” This article discusses the diagnostic approach to focal alopecia in dogs, focusing on distinguishing between pruritic skin disease and inflammatory or non-inflammatory causes; it presents no new experimental results.
163 citations
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October 2001 in “EMBO journal” This study found that endogenous activin plays a crucial role in wound healing and scar formation, as its inhibition led to delayed wound healing and reduced scar size in transgenic mice.
26 citations
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July 2007 in “Wound Repair and Regeneration” This study found that MRL/MpJ mice heal burn wounds with scar formation, experiencing delayed wound closure and impaired myofibroblast development, which contrasts with quicker contraction in BALB/c mice.
21 citations
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October 2007 in “Journal of Investigative Dermatology” Fetuin-A helps wounds heal without scars by promoting cell movement.
16 citations
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August 2019 in “Journal of the Chinese Medical Association” This study reported that adipose-derived stem cells may promote burn wound healing and skin appendage regeneration in a rat model, suggesting a potential approach for improving burn treatments.
13 citations
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December 2012 in “Cells” This study describes how manipulating the actin cytoskeleton, particularly through the gelsolin family proteins, may enhance regenerative healing in mammals, suggesting potential therapeutic pathways for improved wound repair.
9 citations
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June 2020 in “Cell stem cell” This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.
8 citations
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February 2021 in “Journal of Clinical Medicine” This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.
5 citations
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February 2022 in “International Journal of Molecular Sciences” This review discusses the roles of distinct immune cell types in skin wound healing, highlighting findings from animal studies, but provides no new clinical results.
5 citations
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January 2019 in “Elsevier eBooks” This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.
2 citations
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December 2023 in “Advanced science” This review discusses the roles and mechanisms of glycosaminoglycans in wound healing and presents challenges and potential applications for GAG-based biomaterials without reporting new experimental results.
February 2026 in “Exploration” This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.
March 2024 in “Biomedicines” This review examines the mechanisms, recent findings, and strategies to enhance mesenchymal stem cells' therapeutic effects in skin wound healing, but reports no new research results.