13 citations,
November 2015 in “Gene” Let-7b helps alpaca hair grow by reducing TGFβR I protein.
1 citations,
December 2015 in “Journal of the Medical Sciences (Berkala Ilmu Kedokteran)” Transplanting melanocyte stem cells from hair follicles can effectively treat vitiligo.
18 citations,
February 2022 in “Cell Death Discovery” ECM1-modified stem cells can effectively treat liver cirrhosis.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
2 citations,
January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
October 2021 in “Research Square (Research Square)” Melatonin affects certain genes and pathways involved in cashmere goat hair growth.
June 2021 in “Research Square (Research Square)” Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.
1 citations,
May 2017 in “InTech eBooks” Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.
59 citations,
March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.
28 citations,
November 2018 in “Journal of Cellular and Molecular Medicine” CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
245 citations,
January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
132 citations,
August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.
5 citations,
March 2017 in “Biomedical and Pharmacology Journal” Certain growth factors significantly affect hair loss in women with telogen effluvium.
1 citations,
January 2018 in “Recent clinical techniques, results, and research in wounds” Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.
10 citations,
August 2020 in “Acta histochemica” All-trans-retinoic acid stops mink hair growth by affecting cell growth and causing cell death.
Higher TGF-β signaling may increase skin cancer risk in organ transplant recipients.
82 citations,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
9 citations,
November 2018 in “Drug Discovery Today” Using skin stem cells and certain molecules might lead to scar-free skin healing.
156 citations,
December 2012 in “Cell Stem Cell” TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.
11 citations,
February 2018 in “Oncotarget” Lower SMAD2/3 activation predicts more severe skin cancer.
488 citations,
July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
43 citations,
December 2008 in “Molecular biology of the cell” Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.
26 citations,
September 2018 in “Journal of Molecular Cell Biology” Endoglin is crucial for proper hair growth cycles and stem cell activation in mice.
May 2024 in “Molecules/Molecules online/Molecules annual” Plant extracts can help prevent hair loss and promote hair growth.
81 citations,
September 2005 in “The American journal of pathology” Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.
March 2024 in “EMBO molecular medicine” Antiviral drugs, especially daclatasvir, may be a new treatment for a rare skin disease, improving survival and reducing symptoms in mice.
YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.
21 citations,
May 2018 in “Journal of Cosmetic Dermatology” Costunolide helps human hair cells grow and can stimulate hair growth in mice.