13 citations
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December 2017 in “BMC Complementary and Alternative Medicine” In this study, the herbal complex of Houttuynia cordata, Perilla frutescens var. acuta, and green tea promoted hair growth in C57BL/6 mice, enhancing regrowth and follicle development compared to controls.
13 citations
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June 2014 in “Molecular therapy” This study found that a lentiviral array of reporters can identify lineage-specific promoters and pathways in mesenchymal stem cell differentiation, aiding in the prediction of signaling pathway effects.
13 citations
,
December 1991 in “Annals of the New York Academy of Sciences” This study observed that human anagen hair follicles can grow in vitro when maintained serum-free, with possible implications for understanding hair follicle growth mechanisms.
12 citations
,
February 2025 in “Scientific Reports” This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
12 citations
,
December 2020 in “Archives animal breeding/Archiv für Tierzucht” This study found that EDA and EDAR are expressed throughout cashmere goat fetal development and play a critical role in hair follicle formation by influencing gene expression in fibroblasts and epithelial cells.
12 citations
,
March 2016 in “BBA clinical” This study found that intracellular Toll-like receptors were significantly up-regulated in peripheral blood mononuclear cells of alopecia areata patients, suggesting a potential role in inflammatory signaling and pathogenesis.
12 citations
,
September 2014 in “Journal of Food Science and Nutrition” This study suggests that Platycarya strobilacea extract promotes hair growth in mice by enhancing stem cell factor expression, reducing mast cell numbers, and increasing cytokines associated with hair growth.
12 citations
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June 2011 in “Han-guk sikpum gwahakoeji/Han'gug sigpum gwahag hoeji/Han-guk sikpum gwahak hoeji” This study found that MBN, an herbal extract fermented by Lactobacillus plantarum, promoted hair growth and increased related gene expression in C57BL/6 mice.
12 citations
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September 2007 in “Wound repair and regeneration” This study found that in vivo bioluminescence can track Smad2/3-dependent TGF-β signaling during the wound healing process in mice, with signaling increasing after healing rather than immediately post-wounding.
11 citations
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December 2024 in “Stem Cell Research & Therapy” In this study, hUCMSCs-Exo significantly accelerated wound healing in rat perianal fistulas with notable safety, potentially through the activation of the HIF-1α/TGF-β/Smad signaling pathway.
11 citations
,
May 2021 in “Journal of Cosmetic Dermatology” This review discusses the potential use of platelet-rich plasma for treating melasma, suggesting its effectiveness but noting the need for more extensive studies to confirm these findings.
11 citations
,
February 2018 in “Oncotarget” This study observed that reduced activation of SMAD2/3 proteins in cutaneous squamous cell carcinoma tissue compared to adjacent tissue may indicate a tumor suppressor role in disease progression.
11 citations
,
January 2018 in “Acta dermato-venereologica” In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.
11 citations
,
January 2015 in “Journal of cellular physiology” This study suggests that abnormal hair cycles in Hr mutant mice may be caused by HR protein overexpression, which down-regulates miR-31 and increases Tgf-β2 expression.
11 citations
,
September 2014 in “International Journal of Molecular Sciences” This study found that mycophenolate may stabilize β-catenin and counteract interferon-γ-induced catagen changes in human dermal papilla cells, which could promote hair growth.
10 citations
,
August 2024 in “Clinical Cosmetic and Investigational Dermatology” This review reports that natural compounds show promise in slowing skin photoaging by targeting cellular pathways in keratinocytes and fibroblasts. However, comprehensive clinical studies are needed to verify their efficacy and safety.
10 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses mechanisms of wound healing impairment in leptin-deficient murine models used for diabetic research, and reports no new clinical results; the authors emphasize the need for further study.
10 citations
,
May 2021 in “Stem Cell Research & Therapy” In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures.
10 citations
,
November 2020 in “American Journal Of Pathology” The study suggests that integrin β1 is crucial for maintaining liver microstructure and its absence may promote fibrosis by disrupting hepatocyte-extracellular matrix interactions and increasing TGF-β secretion.
10 citations
,
September 2016 in “Animal genetics” In this study, researchers identified a number of differentially expressed genes that may influence wool growth in Aohan fine wool sheep, offering insight into the genetic regulation of wool quality and yield.
10 citations
,
January 2015 in “European journal of pharmacology” In this animal study, ginsenoside Rb1 demonstrated therapeutic effects on hypertrophic scar remodeling, with the highest efficacy observed at a dose of 0.56 mg.
10 citations
,
June 2014 in “Experimental Dermatology” The study found that exogenous decorin administration accelerated the anagen phase and delayed the catagen transition, suggesting it may act as a positive regulator of the hair cycle.
9 citations
,
January 2023 in “International Journal of Biological Sciences” This study suggests that CTHRC1, a protein expressed in cardiac fibroblasts, may improve wound repair and prevent cardiac rupture after myocardial infarction by activating a specific signaling pathway.
9 citations
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February 2022 in “BMC Genomics” This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.
9 citations
,
November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
9 citations
,
January 2017 in “Elsevier eBooks” This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.
9 citations
,
November 2016 in “Archives of Plastic Surgery” In this study, researchers found that a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) promoted hair growth in mice comparably to 3% minoxidil. The L-U mixture stimulated hair growth-promoting genes and suppressed hair loss-related genes, suggesting its potential for hair loss treatments.
9 citations
,
March 2009 in “European Journal of Dermatology” In this animal study, the researchers found that Schisandra nigra extract may promote hair growth by extending the anagen phase and reducing TGF-beta2 expression.
9 citations
,
January 2005 in “Experimental dermatology” The researchers observed that normal murine hair follicles are direct targets for melatonin, with receptor expression varying throughout the hair cycle, suggesting melatonin's role in hair cycle control.
8 citations
,
December 2023 in “International Journal of Molecular Sciences” In this study, successful treatment outcomes with platelet-rich plasma injections in patients with IC/BPS and rUTI were associated with specific cytokine concentrations, particularly lower TNF-α levels.