Therapeutic Effect of Mesenchymal Stem Cells on Histopathological, Immunohistochemical, and Molecular Analysis in Second-Degree Burn Model

May 2021 in “ Stem Cell Research & Therapy ”

Doaa R.I. Abdel-Gawad, Walaa A. Moselhy, Rasha R. Ahmed, Hessah Mohammed Al‐Muzafar, Kamal Adel Amin, Maha M Amin, El‐Shaymaa El‐Nahass, Khaled Abdou

Studysummary In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on second-degree burns in 90 albino rats. The rats were divided into three groups: a control group, a burn model group, and a group where burned animals were injected with BM-MSCs. The results showed that BM-MSCs led to a decrease in wound contraction rate, a regular arrangement of the epidermal layer, and a decrease in the area percentages of ADAMs10 expression. There was also a significant downregulation of transforming growth factor-β (TGF-β), interleukin-6 (IL-6), tumor necrotic factor-α (TNF-α), metalloproteinase-9 (MMP-9), and microRNA-21, and a marked upregulation of heat shock protein-90α (HSP-90α) especially in late stages. The study concluded that BM-MSCs exhibited a powerful healing property through regulating the mediators of wound healing and restoring the normal skin structures, reducing the scar formation and the wound size.

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