Therapeutic Effect of Mesenchymal Stem Cells on Histopathological, Immunohistochemical, and Molecular Analysis in Second-Degree Burn Model

    May 2021 in “ Stem Cell Research & Therapy ”
    Doaa R.I. Abdel-Gawad, Walaa A. Moselhy, Rasha R. Ahmed, Hessah Mohammed Al‐Muzafar, Kamal Adel Amin, Maha M Amin, El‐Shaymaa El‐Nahass, Khaled Abdou
    Image of study
    TLDR Bone marrow-derived stem cells improved healing and reduced scarring in second-degree burns in rats.
    The study investigated the therapeutic effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on second-degree burns in 90 albino rats. The rats were divided into three groups: a control group, a burn model group, and a group where burned animals were injected with BM-MSCs. The results showed that BM-MSCs led to a decrease in wound contraction rate, a regular arrangement of the epidermal layer, and a decrease in the area percentages of ADAMs10 expression. There was also a significant downregulation of transforming growth factor-β (TGF-β), interleukin-6 (IL-6), tumor necrotic factor-α (TNF-α), metalloproteinase-9 (MMP-9), and microRNA-21, and a marked upregulation of heat shock protein-90α (HSP-90α) especially in late stages. The study concluded that BM-MSCs exhibited a powerful healing property through regulating the mediators of wound healing and restoring the normal skin structures, reducing the scar formation and the wound size.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 23 results

      community Stem cells for hair, does it work?

      in Technology  7 upvotes 3 months ago
      Stem cell treatments for hair restoration can be effective, but results vary and depend on factors like the type of stem cells used and timing of treatment. PRP and exosomes have shown some success, while costs and effectiveness differ by location, with South Korea and Turkey offering more affordable options.

      community Lavdik Hair Growth Serum?

      in Product 5 years ago
      A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  327 upvotes 2 years ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

    Similar Research

    5 / 1000+ results