Therapeutic Effect of Mesenchymal Stem Cells on Histopathological, Immunohistochemical, and Molecular Analysis in Second-Degree Burn Model
May 2021
in “
Stem Cell Research & Therapy
”
mesenchymal stem cells bone marrow-derived mesenchymal stem cells BM-MSCs epidermal layer ADAMs10 transforming growth factor-β TGF-β interleukin-6 IL-6 tumor necrotic factor-α TNF-α metalloproteinase-9 MMP-9 microRNA-21 heat shock protein-90α HSP-90α stem cells bone marrow stem cells epidermis TGF-beta TNF-alpha HSP-90
Studysummary In this study, subcutaneous injection of bone marrow mesenchymal stem cells in burned rats significantly improved wound healing by reducing inflammation, scar formation, and wound size, and restoring normal skin structures.
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