Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Healing of Complex Perianal Fistulas in Rats

    December 2024 in “ Stem Cell Research & Therapy ”
    Yafei Lu, Shaohua Huangfu, Chuanxue Ma … Bin Jiang
    Studysummary In this study, hUCMSCs-Exo significantly accelerated wound healing in rat perianal fistulas with notable safety, potentially through the activation of the HIF-1α/TGF-β/Smad signaling pathway.
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    Research cited in this study 2

    1. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    2. Wound Healing: A Cellular Perspective Physiological Reviews · 2018