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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

The removal of the adrenal tumor improved the patient's symptoms and reduced androgen levels, indicating successful surgery.

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Testosterone raises blood pressure and changes kidney protein levels.

The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

Certain gene variations in AKT2 are more common in women with PCOS and are linked to higher levels of specific hormones and symptoms.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.

Spironolactone reduces the enzyme activity that converts testosterone to DHT, helping treat excessive hair growth in women.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Both treatments reduced androgen levels and hair growth in women with hirsutism.

Lower testosterone levels in men may be linked to a higher risk of severe coronary artery disease.

Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

DHT affects testicular development and regulates spermatogenesis in some fish.

The study concludes that a genetic mutation in TFM mice leads to reduced androgen receptor activity, affecting the body's response to male hormones.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.

Men with early balding should be checked for metabolic syndrome, as there's a link between the two.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.