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    GlossaryDihydrotestosterone Synthesis

    enzyme 5-alpha-reductase converts testosterone into potent androgen DHT

    Dihydrotestosterone (DHT) synthesis is the process by which the enzyme 5-alpha-reductase converts testosterone into DHT, a more potent androgen hormone. DHT plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and prostate enlargement.

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      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  106 upvotes 4 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community How many Dut pills does it take to have Franz Kafka's hairline?

      in Satire  48 upvotes 2 years ago
      The post and conversation discuss hair loss treatments and the uncertainty of their results. Some users suggest that artificial hair systems might be the best solution, while others express preference for maintaining a mature hairline rather than aiming for a youthful one.

      community Switched from finasteride to dutasteride - 2 month update

      in Finasteride/Dutasteride  6 upvotes 2 years ago
      The user switched from finasteride to dutasteride for hair loss treatment, but experienced increased libido, itchy scalp, and accelerated hair loss. Another user suggested that genetic variations might cause dutasteride to be less effective and recommended checking for specific genetic markers.