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    Glossary Dihydrotestosterone Synthesis

    enzyme 5-alpha-reductase converts testosterone into potent androgen DHT

    Dihydrotestosterone (DHT) synthesis is the process by which the enzyme 5-alpha-reductase converts testosterone into DHT, a more potent androgen hormone. DHT plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and prostate enlargement.

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    Research 10 of 1000+

    1. Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat Frontiers in Cellular Neuroscience · 2015 · 32 citations
    2. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate Vitamins and hormones · 1976 · 59 citations
    3. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    4. Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts* 1983 · 57 citations
    5. Inhibition of Rat 5<i>α</i>-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of<i>Quercus acutissima</i>Cortex Evidence-based Complementary and Alternative Medicine · 2015 · 37 citations
    6. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004 · 129 citations
    7. Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives. 2002 · 18 citations
    8. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors Bioorganic & Medicinal Chemistry · 2015 · 17 citations
    9. Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions Bioorganic & Medicinal Chemistry Letters · 1998 · 14 citations
    10. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
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    Learn 3 of 16

    1. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
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    Community 2 of 108

    1. Hair growth stimulated by allogenic adipose-derived stem cells supplemented with ATP in a mouse model of dihydrotestosterone-induced androgenetic alopecia Reddit · 13 Jun 2025
    2. [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Reddit · 4 Dec 2019
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