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    Glossary Dihydrotestosterone Synthesis

    enzyme 5-alpha-reductase converts testosterone into potent androgen DHT

    Dihydrotestosterone (DHT) synthesis is the process by which the enzyme 5-alpha-reductase converts testosterone into DHT, a more potent androgen hormone. DHT plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and prostate enlargement.

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    1. Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat Frontiers in Cellular Neuroscience · 2015 · 32 citations
    2. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate Vitamins and hormones · 1976 · 59 citations
    3. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    4. Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts* 1983 · 57 citations
    5. Inhibition of Rat 5<i>α</i>-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of<i>Quercus acutissima</i>Cortex Evidence-based Complementary and Alternative Medicine · 2015 · 37 citations
    6. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004 · 129 citations
    7. Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives. 2002 · 18 citations
    8. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors Bioorganic & Medicinal Chemistry · 2015 · 17 citations
    9. Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions Bioorganic & Medicinal Chemistry Letters · 1998 · 14 citations
    10. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    11. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    12. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages General and Comparative Endocrinology · 2019 · 4 citations
    13. Basics of androgen synthesis and action 2022 · 35 citations
    14. Disruptors of Androgen Action and Synthesis Elsevier eBooks · 2015 · 1 citations
    15. Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2 Steroids · 2017 · 8 citations
    16. Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists Bioorganic & medicinal chemistry letters · 2017 · 3 citations
    17. Trichoscopic evaluation of dental pulp stem cell conditioned media for androgenic alopecia. PubMed · 2023
    18. Sex hormones and acne Clinics in dermatology · 2016 · 76 citations
    19. Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor 2015 · 31 citations
    20. Studies of androgen metabolism and action in cultured hair and skin cells Journal of Steroid Biochemistry · 1986 · 29 citations
    21. Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor. Chemical & Pharmaceutical Bulletin · 2001 · 23 citations
    22. Genetic regulation of the androgen receptor—A study of testicular feminization in the mouse 1975 · 20 citations
    23. Androgenic and anti-androgenic effects of progesterone derivatives with different halogens as substituents at the C-6 position Steroids · 1999 · 19 citations
    24. National consensus on the management of patients with hyperandrogenism (2016) Reproductive Endocrinology · 2016 · 12 citations
    25. Inhibition of lipogenesis and sebum secretion for <i>Lotus corniculatus</i> seed extract in vitro and in vivo International Journal of Cosmetic Science · 2022 · 1 citations
    26. Female Antiandrogens Elsevier eBooks · 2017 · 1 citations
    27. Expanding the therapeutic versatility of clacosterone Journal of the American Academy of Dermatology · 2023
    28. Finasteride Inhibits Melanogenesis throughthe Regulation of Melanocortin 1 Receptorin Melanocytes 한국생물공학회 학술대회 · 2015
    29. Antiandrogens CRC Press eBooks · 2022
    30. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells American journal of physiology. Cell physiology · 2006 · 56 citations