Search

for
Search:

Glossary Dihydrotestosterone Blockers

inhibit the hormone DHT to prevent hair loss

Dihydrotestosterone Blockers, often referred to as DHT Blockers, are substances that inhibit the action or production of dihydrotestosterone (DHT), a hormone linked to hair loss. By reducing DHT levels, these blockers can help prevent hair follicles from shrinking, thereby slowing or stopping hair loss and promoting hair regrowth.

Related Terms

Research

5 / 1000+ results

research New Nonsteroidal Molecules as Blockers of the Steroidogenic Pathway

January 2022 in “Current Enzyme Inhibition”

This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.

research Testosterone Reduces Knee Passive Range of Motion and Expression of Relaxin Receptor Isoforms via 5α-Dihydrotestosterone and Androgen Receptor Binding

23 citations , March 2014 in “International Journal of Molecular Sciences”

The study observed that testosterone reduced knee range of motion in ovariectomized female rats, potentially by downregulating specific relaxin receptor isoforms, with its effects mediated via dihydro-testosterone.

research Androgenetic alopecia: An autosomal dominant disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.

research Comparison of clinical trials with finasteride and dutasteride.

20 citations , January 2004 in “PubMed”

This review discusses the pharmacologic effects, safety, and efficacy of dutasteride and finasteride for BPH, finding similar clinical benefits but greater DHT reduction with dutasteride and reports no new trial results.

View more "dihydrotestosterone blockers" in research →

Community Join

5 / 195 results

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community When you think about it blocking dht is not that big of a deal as it’s made out to be

in Research/Science 7 months ago

Reducing sebum can indirectly lower DHT levels, with treatments like accutane, tretinoin, and green tea extract acting as DHT blockers. Accutane can lower DHT levels by reducing 5α-reductase activity, but its impact on hair varies.

community Oh my god for fucks sake why does creatine cause hair loss.. why can't no one possiblly come with why it causes hair loss

in Research/Science 7 months ago

Creatine is debated for causing hair loss, with some users claiming it raises DHT levels, while others argue it has no significant effect. Despite conflicting opinions, some users report hair loss even when using DHT blockers like finasteride.

community 5 years post hair transplant, 3 months on minoxidil only

326 upvotes 9 months ago

The user had a hair transplant five years ago and started using minoxidil three months ago. Commenters recommend adding finasteride or other DHT blockers to prevent further hair loss and maintain results.

View more "dihydrotestosterone blockers" in community →

Learn

6 / 800 results

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Fluridil

a topical anti-androgen with less systemic involvement

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn dehydroepiandrosterone

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

View more "dihydrotestosterone blockers" in learn →

Experts

— no results

Try a deeper search in experts →

Clinics

— no results

Try a deeper search in clinics →