The Influence of Long-Term Treatment with Cyproterone Acetate or a Cyproterone Acetate-Ethinyl Estradiol Combination on Androgen Levels in Blood of Hirsute Women

January 1980 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”

Marijke Frölich, Hum L. Vader, Sjoukjen T. Walma, H. A. M. De Rooy

cyproterone acetate ethinyl oestradiol androgen androstenedione dihydrotestosterone testosterone sex hormone binding globulin hirsutism CA EE SHBG

TLDR Both treatments reduced androgen levels and hair growth in women with hirsutism.

The study investigated the effects of long-term treatment with cyproterone acetate (CA) alone or combined with ethinyl oestradiol (EE) on androgen levels in 35 hirsute women. Both treatments normalized androstenedione (A) and dihydrotestosterone (DHT) levels within eight months, while testosterone (T) levels only showed a tendency to decrease with the CA + EE combination but normalized with CA alone. The binding capacity of sex hormone binding globulin (SHBG) increased in both treatments, more significantly with CA + EE. Hair growth reduction began after approximately six months of treatment in both groups, with no clinical differences in the rate of regression between the two regimens.

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Research cited in this study

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research The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-Androgen Cyproterone Acetate for Therapy

58 citations, July 1974 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Cyproterone acetate combined with ethinyl estradiol significantly reduced hirsutism in women.

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research Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome

192 citations, September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.